P. Ferrari

Neuronal Synchrony and Critical Bistability: Mechanistic Biomarkers for Localizing the Epileptogenic Network

This paper identifies mechanistic biomarkers for epileptogenicity using computational modeling and SEEG data, showing that combining biomarkers improves seizure zone localization and reveals extended pathological networks beyond the clinically identified seizure zone.

Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants

The paper shows that cross-reactive antibodies, like S309, retain effector functions against emerging Omicron variants despite reduced neutralization.

Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

The paper examines the kinetics, avidity, and cross-reactivity of SARS-CoV-2-specific memory B cells and antibodies in infected and vaccinated individuals over 16 months, finding that MBC maturation enhances resilience to viral escape.

RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity

The paper identifies RAGE as a novel receptor for SARS-CoV-2 that mediates monocyte infection and contributes to COVID-19 severity through single-cell analysis of immune responses.

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

This study shows that hybrid immunity and vaccine boosters provide potent neutralizing activity against Omicron BA.1 and BA.2, while breakthrough infections induce nasal mucosal neutralization and identify an ultrapotent pan-variant antibody.

ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies

The paper identifies monoclonal antibodies that neutralize multiple coronaviruses by targeting the fusion peptide, which becomes exposed upon ACE2 engagement.

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

This study shows that Omicron variant's spike protein has enhanced ACE2 binding and reduces neutralizing activity, but some broadly neutralizing antibodies remain effective.

Istaroxime metabolite PST3093 selectively stimulates SERCA2a and reverses disease-induced changes in cardiac function

This paper investigates PST3093, a metabolite of istaroxime, showing it selectively stimulates SERCA2a and improves cardiac function in a rat model of diabetic cardiomyopathy.

A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machinery

This paper identifies a human antibody that broadly neutralizes betacoronaviruses by targeting the stem helix, showing protection against SARS-CoV-2 and potential for vaccine design.

Clonal dissection of immunodominance and cross-reactivity of the CD4+ T cell response to SARS-CoV-2

The paper identifies immunodominant and cross-reactive CD4+ T cell epitopes in SARS-CoV-2, showing their recognition in 93% of patients and potential for vaccine design.

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

The paper shows the N439K SARS-CoV-2 spike variant maintains replication fitness while evading antibody neutralization.