A. Rinaldi

PI3Kδ activation, IL6 over-expression, and CD37 loss cause resistance to the targeting of CD37-positive lymphomas with the antibody-drug conjugate naratuximab emtansine

This paper identifies two resistance mechanisms to the CD37-targeting ADC naratuximab emtansine in lymphoma cell lines and suggests combination therapies to overcome resistance.

Mitochondrial DNA released by senescent cells triggers immunosuppression in cancer

This study shows that mtDNA released by senescent cells triggers immunosuppression via PMN-MDSCs, and inhibiting this pathway enhances therapy-induced senescence in cancer.

Cancer-specific association between Tau (MAPT) and cellular pathways, clinical outcome, and drug response

The paper analyzes MAPT expression across cancer types to show its association with cancer hallmarks, clinical outcomes, and drug response, highlighting context-specific roles.

Tau protein modulates an epigenetic mechanism of cellular senescence

The paper investigates how Tau protein affects epigenetic regulation of cellular senescence by analyzing transcriptome data from Tau-depleted cells.

ERBB4-mediated signaling is a mediator of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms

This study identifies ERBB4-mediated signaling as a mechanism of resistance to BTK and PI3K inhibitors in B cell lymphoid neoplasms and shows that targeting ERBB signaling can restore sensitivity.

Assessment of lisavanbulin (BAL101553) as an anti-lymphoma agent

This study evaluates lisavanbulin's anti-lymphoma activity and EB1 expression in DLBCL, showing potent in vitro cytotoxicity and potential clinical relevance.

Myc controls IL-15-driven expansion and translational machinery of NK cells

This study shows that Myc is essential for NK cell development, expansion, and anticancer immunity by regulating translational machinery and IL-15 responses.

IL-1α secreted by subcapsular sinus macrophages promotes melanoma metastasis in the sentinel lymph node by upregulating STAT3 signaling in the tumor.

This study shows that IL-1α from subcapsular sinus macrophages promotes melanoma metastasis by enhancing STAT3 signaling in tumor cells, and blocking this pathway reduces metastasis.

Single-cell profiling in COVID-19 associated acute kidney injury reveals patterns of tubule injury and repair in human

This study uses single-nucleus RNA sequencing to analyze kidney tubule injury and repair in COVID-19 patients, identifying cell state transitions and reparative mechanisms.

Dual Functions of SPOP and ERG Dictate Androgen Therapy Responses in Prostate Cancer

This study shows that SPOP and ERG mutations in prostate cancer have opposing effects on androgen receptor signaling and therapy response.