Author

S. K. McBrayer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

K. G. Abdullah· 2 shared L. C. Gattie· 2 shared M. R. Savani· 2 shared T. E. Richardson· 2 shared W. H. Hicks· 2 shared A. Perciaccante· 1 shared B. C. Lega· 1 shared B. C. Smith· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

K. G. Abdullah

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivJan 18, 2024

Matched three-dimensional organoids and two-dimensional cell lines of melanoma brain metastases mirror response to targeted molecular therapy

W. H. Hicks, L. C. Gattie, J. I. Traylor…·K. G. Abdullah

This study develops matched patient-derived organoids and cell lines from melanoma brain metastases to evaluate responses to targeted therapies, finding both models respond to BRAF and MEK inhibitors.

DOI 10.1038/s41598-024-76583-8

humanexperimental assay

Cancer BiologybioRxivMay 29, 2023

Stable isotope tracing in human plasma-like medium reveals metabolic and immune modulation of the glioblastoma microenvironment

M. R. Savani, M. El Shami, L. C. Gattie…·K. G. Abdullah

This paper develops an in vitro method using human plasma-like medium to study glioma metabolism and immune interactions, revealing microenvironment-dependent metabolic features and immune responses.

DOI 10.1093/neuonc/noaf248

humanspatial transcriptomics

Cancer BiologybioRxivNov 30, 2021

A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

S. PAL, J. P. Kaplan, H. Nguyen…·D. Haas-Kogan

This paper identifies a druggable metabolic vulnerability in diffuse midline glioma through a CRISPR screen, showing that inhibition of DHODH reduces pyrimidine biosynthesis and extends survival in mouse models.

DOI 10.1016/j.ccell.2022.07.012

mouseproteomics