S. Pal

Phenotypic screens identify biologic regulators of nanoparticle uptake in diffuse midline glioma

The paper identifies biologic regulators of nanoparticle uptake in diffuse midline glioma using CRISPR screens and functional assays, finding CTNNB1 and pathway members as key modulators.

Decoy effect in shoaling decision making in zebrafish (Danio rerio)

This study examines the decoy effect in zebrafish shoaling decisions, finding sex-specific differences based on the order of choice presentation.

Acinetobacter baumannii DacC influences cell shape, biofilm formation, and physiological fitness by manifesting DD-carboxypeptidase and β-lactamase dual-enzyme activities

This study identifies DacC in Acinetobacter baumannii as a dual-enzyme with DD-carboxypeptidase and β-lactamase activities that affect cell shape, biofilm formation, and antibiotic susceptibility.

Evaluation in mice of cell-free produced CT584 as a Chlamydia vaccine antigen

This study evaluates CT584, a Chlamydia antigen produced via cell-free synthesis, as a vaccine in mice, finding it induces antibodies but not protection against infection.

Stochastic modelling of single-cell gene expression adaptation reveals non-genomic contribution to evolution of tumor subclones

The paper models gene expression adaptation in tumor subclones using stochastic processes and finds non-genetic mechanisms drive subclonal evolution and treatment response.

Valproic Acid Treatment Enhances Chromosome Flexibility and Electron Transport in MCF7 Breast Cancer Cells

This study examines how Valproic Acid affects chromosome flexibility and electron transport in MCF7 breast cancer cells using atomic force microscopy and electron transport analysis.

Neuropilin-1 controls vascular permeability through juxtacrine regulation of endothelial adherens junctions

This study shows that Neuropilin-1 (NRP1) on perivascular cells modulates VEGFA/VEGFR2 signaling in endothelial cells, affecting vascular permeability in a tissue-specific manner.

Extracellular matrix scaffold-assisted tumor vaccines induce tumor regression and long-term immune memory

This study shows that ECM scaffolds enhance cancer vaccine efficacy by promoting cytotoxic immunity without compromising wound healing immune responses.

Identifying Selectivity Filters in Protein Biosensor for Ligand Screening

The paper identifies selectivity filters in MopR, a bacterial phenol biosensor, that screen ligands based on chemical features and size, revealing conserved mechanisms for ligand selection.

Enhanced transcriptional strength of HIV-1 subtype C minimizes gene expression noise and confers stability to the viral latent state

This study shows that enhanced transcriptional strength in HIV-1C LTRs reduces gene expression noise and stabilizes viral latency.

Reward quantity discrimination in an associative learning task in wild zebrafish (Danio rerio)

This study tests reward quantity discrimination in wild zebrafish using an operant conditioning task and finds some fish can discriminate between stimuli associated with different rewards.

Claudin5 protects the peripheral endothelial barrier in an organ and vessel type-specific manner

The paper identifies Claudin5's organ- and vessel-type-specific role in maintaining endothelial barrier integrity through single-cell RNAseq analysis and functional studies in mice.

DNA-functionalized Gold Nanorods for Targeted Triple-modal Optical Imaging and Photothermal Therapy of Triple-negative Breast Cancer

This paper develops DNA-functionalized gold nanorods for triple-modal optical imaging and photothermal therapy of triple-negative breast cancer, showing preferential tumor accumulation and effective thermal ablation.

A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma

This paper identifies a druggable metabolic vulnerability in diffuse midline glioma through a CRISPR screen, showing that inhibition of DHODH reduces pyrimidine biosynthesis and extends survival in mouse models.

Interaction of hypoxia and nicotine acetylcholine receptor signaling network reveals a novel mechanism for lung adenocarcinoma progression in never-smokers

The paper investigates the interaction between hypoxia and nicotine acetylcholine receptor signaling in lung adenocarcinoma, finding that hypoxia increases nAChR-7 levels and stabilizes HIF-1 through a feedback loop, contributing to disease progression in never-smokers.

A Serpin27A-dependent Toll Signaling Underlies Host Genetics of Cancer Resistance in Drosophila

This study identifies a Serpin27A-dependent Toll signaling pathway in Drosophila that mediates cancer resistance through NF-κB-mediated tumor cell death.

Gibberellins target shoot-root growth, morpho-physiological and molecular pathways to induce cadmium tolerance in mung bean

This study investigates how gibberellins (GAs) mitigate cadmium (Cd) toxicity in mung bean by improving growth, physiology, and gene expression.

Coupled social-land dynamics and the future of sustainable consumption

This study models coupled social-land dynamics to project future global land use under various socio-economic scenarios, showing how feedbacks can significantly alter land use projections.

Root specific plasticity induced by paclobutrazol confers improved deficit irrigation tolerance and agronomic performance in maize

This study shows that paclobutrazol improves drought tolerance and agronomic performance in maize by enhancing root developmental traits under deficit irrigation.

Emergence of multiple variants of SARS-CoV-2 with signature structural changes

This study analyzes SARS-CoV-2 genome divergence and identifies structural changes in viral proteins across four distinct genetic groups.

Modeling gene expression evolution with EvoGeneX uncovers differences in evolution of species, organs and sexes

The paper introduces EvoGeneX to model gene expression evolution, revealing purifying selection in most genes and sex-specific evolutionary dynamics in Drosophila.

Physico-biochemical and molecular responses of Acacia auriculiformis to salinity stress

This study investigates the physiological, molecular, and antioxidant responses of Acacia auriculiformis to varying salinity levels, identifying key enzymes, metabolites, and gene expression patterns associated with salt tolerance.

Stability of Commonly Used Haematological Parameters in Samples Stored at 33°C, 22°C and 4°C

This study evaluates the stability of haematological parameters at different storage temperatures, finding that most parameters degrade rapidly at 33°C but some remain stable.