S. Kleiven

Molecular dynamics study of stiffness and rupture of axonal membranes

This study uses molecular dynamics to investigate how lipid composition and protein concentration affect axonal membrane rupture, finding that node-of-Ranvier membranes rupture at lower strains than myelin.

The white matter fiber tract deforms most in the perpendicular direction during in vivo volunteer impacts

This study quantifies different types of white matter strain during in vivo impacts and finds that perpendicular normal strain is the largest.

Brain strain rate response: addressing computational ambiguity and experimental data for model validation

The paper clarifies two strain rate calculation methods for TBI modeling and shows scheme-dependent results in experimental and FE model data.

The Presence of the Temporal Horn Exacerbates the Vulnerability of Hippocampus during Head Impacts

This study uses computational models to show that the temporal horn increases hippocampal vulnerability during head impacts by increasing strain and strain rate in specific subfields.

Injury risk functions for the four primary knee ligaments

This study develops Injury Risk Functions (IRFs) for four knee ligaments using PMHS data and virtual values, providing first-of-their-kind injury prediction tools.

Influence of Strain Post-Processing on Brain Injury Prediction

This study evaluates how different strain post-processing methods affect brain injury prediction and ranking using finite element head models.

Towards a comprehensive delineation of white matter tract-related deformation

This study introduces three new tract-related strain measures to improve concussion prediction in finite element head models by analyzing white matter deformation during impacts.

White matter tract-oriented deformation is dependent on real-time axonal fiber orientation

This study shows that real-time axonal fiber orientation during impact affects tract-oriented strain in white matter, increasing deformation magnitude and distribution.

An anatomically accurate and personalizable head injury model: Significance of brain and white matter tract morphological variability on strain

This paper develops a subject-specific finite element head model with accurate white matter tracts and evaluates its sensitivity to anatomical variability in predicting brain strain during concussive loading.

Localized axolemma deformations suggest mechanoporation as axonal injury trigger

This study uses simulations to show that axonal injury can result from membrane pore formation due to localized deformations, aligning with known injury thresholds.