S. Meng

Dynamic Electrical Stimulation Promotes hiPSC-CM Differentiation and Functionality

This study shows that dynamic electrical stimulation improves hiPSC-CM differentiation, functionality, and transcriptomic pathway enrichment compared to static or no stimulation.

A high-fidelity in vitro model of the human intestinal epithelium

This paper develops an in vitro model of the human intestinal epithelium that closely mimics in vivo cell types using single-cell transcriptomics and a biomedical foundation model.

The Natural Products Discovery Center: Release of the First 8490 Sequenced Strains for Exploring Actinobacteria Biosynthetic Diversity

The paper introduces the Natural Products Discovery Center, releasing 8490 sequenced Actinobacteria strains and highlighting their taxonomic and biosynthetic diversity.

MCT4 and CD147 co-localize with MMP14 in invadopodia and autolysosomes and collectively stimulate breast cancer cell invasion by increasing extracellular matrix degradation

This study shows MCT4 and CD147 work together in breast cancer cells to enhance invasion by boosting ECM degradation through interactions with MMP14.

miR-252 targeting temperature receptor CcTRPM to mediate the transition from summer-form to winter-form of Cacopsylla chinensis

This study identifies a temperature receptor and miRNA pathway that mediates the seasonal morphological transition in Cacopsylla chinensis.

IL-15 enhances functional properties and responses of CD28-negative CD4+ cytotoxic T cells expanded in Systemic lupus erythematosus

The paper identifies CD4+CD28- cytotoxic T cells in SLE patients and shows IL-15 enhances their expansion and cytotoxic function, with JAK3 inhibition blocking this effect.

HIV-2 Immature Particle Morphology Provides Insights into Gag Lattice Stability and Virus Maturation

This study determines the 3D structure of HIV-2 immature Gag lattice using cryo-EM and identifies structural features critical for particle release and infectivity.

Influence of Strain Post-Processing on Brain Injury Prediction

This study evaluates how different strain post-processing methods affect brain injury prediction and ranking using finite element head models.

Killed whole genome-reduced bacteria surface-expressed coronavirus fusion peptide vaccines protect against disease in a porcine model

This paper develops a bacterial vaccine platform expressing coronavirus fusion peptides on genome-reduced E. coli, showing protection against disease in pigs without sterilizing immunity.

Newcastle disease virus induced ferroptosis through p53-SLC7A11-GPX4 axis mediated nutrient deprivation in tumor cells

This study shows that Newcastle disease virus induces ferroptosis in tumor cells via the p53-SLC7A11-GPX4 pathway, leading to nutrient deprivation and cell death.

Evaluation validation of a qPCR curve analysis method and conventional approaches

The paper evaluates a new qPCR curve analysis method, CqMAN, against existing approaches using clinical and dilution datasets, showing it is comparable and suitable for qPCR data processing.

Clinical Characteristics and Risk of Second Primary Lung Cancer After Cervix Cancer: A Population-Based Study

This study compares clinical characteristics and prognosis of second primary non-small cell lung cancer after cervical cancer with first primary non-small cell lung cancer using SEER data.

Nuclear actin regulates inducible transcription by enhancing RNA polymerase II clustering

The paper shows nuclear actin enhances RNA polymerase II clustering during inducible transcription, facilitating rapid gene expression in response to stimuli like serum and interferon-gamma.

Synthetic standards combined with error and bias correction improves the accuracy and quantitative resolution of antibody repertoire sequencing in human naive and memory B cells