Genome-wide Functional Characterization of Escherichia coli Promoters and Sequence Elements Encoding Their Regulation
G. Urtecho, K. Insigne, A. D. Tripp, M. Brinck, N. B. Lubock, C. Acree, H. Kim, T. Chan, S. Kosuri
The paper characterizes E. coli promoters and regulatory elements using a genomically-encoded assay, identifying 2,228 promoters and 3,317 regulatory elements, but finds predicting promoter activity from sequence remains challenging.
bioRxiv · Jan 4, 2020 · PreprintMicrobiology