T. Chan

Tobacco Smoke Exposure is Characterized by a Distinct Nasal Rhinotype in a Pediatric Population

The paper examines the impact of secondhand tobacco smoke exposure on the nasal microbiome in children, finding a distinct microbial rhinotype associated with higher cotinine levels.

The MIF SNP rs755622 is a germline determinant of tumor immune activation in Glioblastoma

The paper identifies a germline SNP, rs755622, associated with increased leukocyte infiltration in glioblastoma and links it to lactotransferrin expression as a potential biomarker for immune activation.

Immune determinants of the association between tumor mutational burden and immunotherapy response across cancer types

The paper investigates how immune factors influence the predictive power of tumor mutational burden (TMB) for immunotherapy response across cancer types.

IRF8 Governs Tumor-Associated Macrophage Control of T Cell Exhaustion

This study identifies IRF8 as a key factor in tumor-associated macrophages (TAMs) that induce T cell exhaustion by presenting cancer antigens, and shows its association with poor patient survival in renal cell carcinoma.

Differential RNA editing between epithelial and mesenchymal tumors impacts mRNA abundance in immune response pathways

The paper identifies differential RNA editing between epithelial and mesenchymal tumors and shows its impact on immune response pathways through ILF3-mediated transcript stabilization.

TGFβ Suppresses Type 2 Immunity to Cancer

This study shows that blocking TGFβ signaling in CD4+ T cells enhances type 2 immunity, promoting tumor healing and halting cancer progression through IL-4-mediated vasculature repair.

Millipede genomes reveal unique adaptation of genes and microRNAs during myriapod evolution

This paper sequenced two millipede genomes, revealing unique genomic features, defense systems, and microRNA regulation mechanisms in myriapods.

Genome-wide Functional Characterization of Escherichia coli Promoters and Sequence Elements Encoding Their Regulation

The paper characterizes E. coli promoters and regulatory elements using a genomically-encoded assay, identifying 2,228 promoters and 3,317 regulatory elements, but finds predicting promoter activity from sequence remains challenging.

ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup

Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions

This study identifies prevalent oncogenic gene fusions in myoepithelial carcinoma through genomic analysis, highlighting TGFBR3-PLAG1 as a key fusion and potential therapeutic target.