Author

S. L. Manning

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:variant calling· 1

Frequent Co-Authors

A. D. Rhim· 1 shared A. Maitra· 1 shared B. B. Bharati· 1 shared D. B. Zhen· 1 shared D. M. Simeone· 1 shared D. N. Rupani· 1 shared E. D. Pratt· 1 shared E. Qiao· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. D. Rhim

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2 papers

Recent·Most cited

Programmable in vivo CRISPR activation elucidates the oncogenic and immunosuppressive role of MYC in lung adenocarcinoma

F. I. Thege, D. N. Rupani, B. B. Bharati, S. L. Manning, A. Maitra, A. D. Rhim, S. M. Woermann

This study uses CRISPR activation to show MYC promotes lung cancer growth and creates an immunosuppressive tumor environment, suggesting combined MYC/immune therapies could benefit patients.

bioRxiv · Dec 9, 2021 · PreprintCancer Biology

Multiplex Enrichment and Detection of Rare KRAS Mutations in Liquid Biopsy Samples using Digital Droplet Pre-Amplification

E. D. Pratt, R. W. Cowan, S. L. Manning, E. Qiao, H. Cameron, K. Schradle, D. M. Simeone, D. B. Zhen

The paper introduces MED-Amp, a method for highly sensitive detection of rare KRAS mutations in liquid biopsy samples, achieving 86% detection in metastatic pancreatic cancer plasma.

bioRxiv · Apr 24, 2019Bioengineering