Identification of clinical combination therapies to induce durable responses in kidney cancers
H.-w. Lue, D. S. Derrick, S. Rao, A. VanGaest, L. Cheng, J. Podolak, S. Lawson, C. Xue, D. Garg, R. White, C. W. Ryan, J. M. Drake, A. Ritz, L. M. Heiser, G. V. Thomas
This study identifies a synergistic combination of cabozantinib and dasatinib that reduces viability and induces tumor regression in NCCRCC, with mechanisms involving MAPK-ERK pathway suppression.
bioRxiv · Jul 25, 2020 · PreprintCancer Biology