R. White

Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri

This study uses zebrafish to identify host factors, like gpr84, that influence susceptibility to Shigella flexneri infection through transcriptional profiling.

An autoactive NB-LRR gene causes Rht13 dwarfism in wheat

The paper identifies Rht13, an autoactive NB-LRR gene that causes dwarfism in wheat, offering a new approach for semidwarfing in crops.

Modeling the effects of genetic and diet induced obesity on melanoma progression in zebrafish.

The paper develops a zebrafish model to study how genetic and diet-induced obesity affect melanoma progression, finding sex-specific differences in tumor incidence.

Electrical activity between skin cells regulates melanoma initiation

The paper shows GABAergic signaling between keratinocytes and melanoma cells promotes melanoma initiation via BRAFV600E, with electrical activity regulating oncogenic competence.

Multi-environment QTL analysis delineates a major locus associated with homoeologous exchanges for water-use efficiency and seed yield in allopolyploid Brassica napus

This study identifies a major QTL on chromosome A09 associated with water-use efficiency and seed yield in Brassica napus, linked to homoeologous exchanges and gene expression differences.

Digging roots is easier with AI

This study demonstrates that using CNN-based software like RootPainter can significantly reduce time and effort in root quantification by accurately analyzing root images with and without debris.

An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish

The paper develops a transgenic reporter to track lipid droplet dynamics in zebrafish and melanoma cells, revealing nitric oxide's role in regulating lipid droplets in both contexts.

Cell state diversity promotes metastasis through heterotypic cluster formation in melanoma

This study shows that melanoma metastasis is promoted by heterotypic clusters formed between proliferative and invasive cell states, mediated by TFAP2.

Identification of clinical combination therapies to induce durable responses in kidney cancers

This study identifies a synergistic combination of cabozantinib and dasatinib that reduces viability and induces tumor regression in NCCRCC, with mechanisms involving MAPK-ERK pathway suppression.

Development of caecaloids to study host-pathogen interactions: new insights into immunoregulatory functions of Trichuris muris extracellular vesicles in the caecum

This paper develops a caecal organoid model to study host-pathogen interactions, revealing immunoregulatory effects of Trichuris muris extracellular vesicles on caecal epithelium.

Structure and functional analysis of the Legionella chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation

This study characterizes the structure and function of Legionella pneumophila's chitinase ChiA, revealing its role in mucin degradation and bacterial pathogenesis.

Unveiling Crucivirus Diversity by Mining Metagenomic Data

This study identifies and characterizes 451 new crucivirus genomes and ten CP-encoding elements through metagenomic data analysis, revealing high sequence diversity and frequent recombination.

Manumycin Polyketides Act as Molecular Glues Between UBR7 and P53 to Impair Breast Cancer Pathogenicity

The paper identifies manumycin polyketides as molecular glues that bind UBR7 and P53, impairing breast cancer pathogenicity through p53 activation and cell death.

A New Mathematical Model for Tumor Growth, Reduction and Metastasis, Validation with Zebrafish Melanoma and Potential Implications for Dormancy and Recurrence

This paper develops a population balance model of tumor growth, reduction, and metastasis, validated with zebrafish melanoma data and human hepatocellular carcinoma data, showing gender-dependent tumor reduction and implications for dormancy and recurrence.

Professional medical writing support and the quality, ethics and timeliness of clinical trial reporting: a systematic review

This study reviews eight observational studies showing that professional medical writing support improves clinical trial reporting quality and may enhance publication timeliness.

Partial correlation analysis of transcriptomes helps detangle the growth and defense network in spruce

The paper uses partial correlation analysis to identify gene networks involved in the growth-defense trade-off in spruce, finding a key terpenoid ABC transporter gene.

Improving the Generation and Selection of Virtual Populations in Quantitative Systems Pharmacology Models

The paper improves the generation of virtual populations in QSP models by using alternative optimization algorithms and objective functions to reduce the number of required virtual patients while maintaining diversity.