C. Xue

SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

Cryptococcosis, tuberculosis, and a kidney cancer fail to fit the atherosclerosis paradigm for foam cell lipid content

The paper investigates lipid accumulation in foam cells across different diseases and finds that lipid content varies by disease and microenvironment.

In planta exploitation of leaf apoplastic compounds: a window of opportunity for spatiotemporal studies of apoplastic metabolites, hormones and physiology

This paper introduces a non-invasive method to extract leaf apoplastic solutes over time with high spatial resolution, revealing apoplastic abscisic acid gradients and kaempferol glycoside accumulation in response to salinity.

Atherosclerosis is a smooth muscle cell-driven tumor-like disease

This study shows atherosclerosis shares tumor-like features with smooth muscle cells, including genomic instability and cancer gene networks, and demonstrates anti-cancer drugs can treat it.

Development of a heat-killed fbp1 mutant strain as a therapeutic agent to treat invasive Cryptococcus infection

This paper demonstrates that heat-killed fbp1 mutant cells (HK-fbp1) can protect against lethal Cryptococcus neoformans infection as both a prophylactic vaccine and a therapeutic agent, with T cells mediating protection and early treatment being critical.

Retinoic acid signaling modulates smooth muscle cell phenotypic switching in atherosclerosis through epigenetic regulation of gene expression

This study shows that retinoic acid signaling reduces SEM cell formation and atherosclerosis by epigenetically repressing SEM cell marker genes through RAR/EZH2 complex recruitment and histone modification changes.

KAI2-KL signalling regulates root hair elongation under magnesium deficiency by activating auxin, ethylene, and nitric oxide biosynthesis and signalling genes.

A Long-Circulating Vector for Aptamers Based upon Polyphosphodiester-Backboned Molecular Brushes

This paper develops a long-circulating molecular brush to enhance aptamer stability and bioactivity in vivo.

A Genome-wide CRISPR Screen Identifies WDFY3 as a Novel Regulator of Macrophage Efferocytosis

This study identifies WDFY3 as a novel regulator of macrophage efferocytosis through a genome-wide CRISPR screen, revealing its role in actin depolymerization and lysosomal acidification.

Three-dimensional drug screen identifies HDAC inhibitors as therapeutic agents in mTORC1-driven lymphangioleiomyomatosis

A 3D drug screen identified HDAC inhibitors as effective against mTORC1-driven lymphangioleiomyomatosis by reducing invasion and selectively killing TSC2-/- cells.

Adipocyte Tribbles1 Regulates Plasma Adiponectin and Plasma Lipids in Mice

This study shows that adipocyte Trib1 regulates plasma adiponectin, cholesterol, and triglycerides in mice, confirming human genetic associations and revealing a novel mechanism for Trib1's role in lipid metabolism.

Identification of clinical combination therapies to induce durable responses in kidney cancers

This study identifies a synergistic combination of cabozantinib and dasatinib that reduces viability and induces tumor regression in NCCRCC, with mechanisms involving MAPK-ERK pathway suppression.

Quantitative partition of the rhizosphere microbiota assembly processes

This paper introduces a method to quantitatively partition rhizosphere microbiota assembly forces using ordination metrics, aiming to assess plant contributions and soil health.

Human condensin I and II drive extensive ATP-dependent compaction of nucleosome-bound DNA

This study shows human condensin I and II compact nucleosome-bound DNA through ATP-dependent motor activity, forming reversible DNA loops without displacing nucleosomes.