Integrated germline and somatic features reveal divergent immune pathways driving ICB response
T. J. Sears, M. Pagadala, A. Castro, K.-H. Lee, J. Kong, K. Tanaka, S. Lippman, M. J. Zanetti, H. Carter
This paper uses machine learning to predict ICB response by integrating germline and somatic features, revealing differences in immune pathways and clinical outcomes between MHC-I and MHC-II neoantigen reliant tumors.
bioRxiv · Jan 12, 2024 · PreprintCancer Biology