H. Carter

CD103+ Dendritic Cell - Fibroblast Crosstalk via TLR9 and AHR Signaling Drives Lung Fibrogenesis

This study identifies CD103+ dendritic cell-fibroblast crosstalk via TLR9 and AHR signaling as a driver of lung fibrosis in IPF, showing that inhibiting AHR signaling reduces fibrosis.

Integrated germline and somatic features reveal divergent immune pathways driving ICB response

This paper uses machine learning to predict ICB response by integrating germline and somatic features, revealing differences in immune pathways and clinical outcomes between MHC-I and MHC-II neoantigen reliant tumors.

Functional Genomics of Gastrointestinal Escherichia coli Isolated from Patients with Cancer and Diarrhea

The paper investigates E. coli strains from cancer patients with diarrhea, finding novel adherence patterns and high antibiotic resistance gene carriage.

Incongruence between transcriptional and vascular pathophysiological cell states

This study compares the vascular phenotypes and transcriptional states of Notch pathway mutants, revealing discrepancies between molecular changes and vascular pathology.

Melanoma clonal subline analysis uncovers heterogeneity-driven immunotherapy resistance mechanisms

The paper analyzes melanoma clonal sublines to uncover how intratumoral heterogeneity drives resistance to immunotherapy.

Rab11-FIP1C is dispensable for HIV-1 replication in primary CD4+ T cells but its role is cell-type-dependent in immortalized human T-cell lines

This study shows FIP1C is not essential for HIV-1 replication in primary CD4+ T cells but has cell-type-dependent effects in T-cell lines.

Mitonuclear interactions produce extreme differences in response to redox stress

The paper examines how mitonuclear incompatibilities affect redox stress response in Drosophila, showing genotype-specific effects on respiration and glutathione levels.

The landscape of extrachromosomal circular DNA in medulloblastoma

This study identifies ecDNA in 18% of medulloblastoma patients, linking it to higher relapse and mortality rates and suggesting enhancer rewiring as an oncogenic mechanism.

Autoimmune Alleles at the Major Histocompatibility Locus Modify Melanoma Susceptibility

This study shows that MHC-I autoimmune alleles are associated with reduced melanoma risk and later diagnosis age, independent of existing polygenic risk scores.

Effect of Substrate Stiffness on Human Intestinal Enteroids Infectivity by Enteroaggregative Escherichia coli

This study shows that substrate stiffness affects the adherence of EAEC bacteria to human intestinal enteroids, with softer hydrogels promoting larger bacterial aggregates.

Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

The paper identifies germline variants associated with the tumor immune microenvironment, linking them to cancer risk and immunotherapy response.

MHC-II constrains the natural neutralizing antibody response to the SARS-CoV-2 spike RBM in humans

The paper investigates how MHC-II constraints affect the generation of neutralizing antibodies against the SARS-CoV-2 spike RBM, finding poor peptide binding and potential cross-reactivity with microbial peptides.

The unfolded protein response links tumor aneuploidy to local immune dysregulation

This study links tumor aneuploidy to local immune dysregulation through the unfolded protein response (UPR), showing increased UPR activity and reduced cytotoxicity in high aneuploidy tumors.

IRE1? regulates macrophage polarization, PD-L1 expression and tumor survival

This study shows that IRE1 regulates macrophage polarization, PD-L1 expression, and tumor survival in mice and humans.

Germline and somatic genetic variants in the p53 pathway interact to affect cancer risk, progression and drug response

The paper investigates interactions between germline and somatic variants in the p53 pathway to show their combined effects on cancer risk, progression, and treatment response.

Exposure to unpredictable trips and slips while walking can improve balance recovery responses with minimum predictive gait alterations

This study shows that repeated exposure to unpredictable slips and trips improves balance recovery without requiring predictive gait changes.