Author

T. J. Sears

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

A. Castro· 1 shared H. Carter· 1 shared J. Kong· 1 shared K. Tanaka· 1 shared K.-H. Lee· 1 shared M. J. Zanetti· 1 shared M. Pagadala· 1 shared S. Lippman· 1 shared

Activity by Year

2024-2024 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperCancer Biology

A. Castro

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintJan 12, 2024

Integrated germline and somatic features reveal divergent immune pathways driving ICB response

T. J. Sears, M. Pagadala, A. Castro…·H. Carter

This paper uses machine learning to predict ICB response by integrating germline and somatic features, revealing differences in immune pathways and clinical outcomes between MHC-I and MHC-II neoantigen reliant tumors.

DOI 10.1101/2024.01.12.575430

humanbulk RNA-seq

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