Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase
A. N. Rizo, J. Lin, S. N. Gates, E. Tse, S. M. Bart, L. M. Castellano, F. DiMaio, J. Shorter, D. R. Southworth
The paper determines the cryo-EM structure of a hyperactive ClpB variant bound to casein and ATPγS to elucidate its substrate gripping and translocation mechanism.
bioRxiv · Sep 26, 2018Biophysics