J. Lin

An Updated Structure of Oxybutynin Hydrochloride

This study determines the 3D structure of oxybutynin hydrochloride using MicroED and reveals insights into its binding mechanism with the M3 muscarinic receptor.

Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants

This study uses MicroED and molecular docking to determine the atomic structures and binding mechanisms of five common antidepressants from commercial powder samples.

Single-molecule analysis reveals the phosphorylation of FLS2 governs its spatiotemporal dynamics and immunity

This study shows phosphorylation of FLS2 at Ser-938 affects its dynamics and immune response by directing it to AtRem1.3 nanodomains.

Synergically enhanced anti-tumor immunity of in vivo CAR by circRNA vaccine boosting

This study develops circRNA-based in vivo CAR and vaccines that synergistically enhance anti-tumor immunity in mice.

Discovery of the missing cytochrome P450 monooxygenase cyclases that conclude glyceollin biosynthesis in soybean

This study identifies three cytochrome P450 monooxygenase cyclases responsible for the final steps of glyceollin biosynthesis in soybean.

Physical constraints and biological regulations underlie universal osmoresponses

The paper develops a theory integrating physical constraints and biological regulations to explain universal osmoresponses in microorganisms, predicting growth thresholds and growth rate changes under osmotic stress.

Occurrence, risk assessment of antibiotics and antimicrobial resistance in Escherichia coli in typical rivers of Sichuan

This study assesses antibiotic and antimicrobial resistance in Escherichia coli from Sichuan rivers, finding high contamination and resistance rates, with specific antibiotics linked to ecological risk.

Biochemical characterization of extended-spectrum β-lactamases from Akkermansia genus

The paper characterizes β-lactamases from Akkermansia species, showing they exhibit extended-spectrum activity and lack transferable resistance genes.

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

This study identifies ADGRA3 as a GPCR that promotes adipose thermogenesis through constitutive activity and the Gs-PKA-CREB axis, with hesperetin as a potential agonist for therapeutic obesity treatment.

Negative regulation of Activation-Induced Cytidine Deaminase gene transcription in developing B cells by a PU.1-interacting intronic region

The paper identifies a PU.1-interacting intronic region that negatively regulates Aicda transcription in developing B cells.

A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by Candida albicans

This study identifies sulfated glycosaminoglycans as targets of candidalysin, a virulence factor in C. albicans, and shows that blocking these interactions can protect epithelial cells from fungal damage.

Design principles to tailor Hsp104 therapeutics

This paper identifies design principles for modifying Hsp104 to enhance its therapeutic potential by tuning its collaboration with Hsp70 and Hsp40.

Mechanically Sheared Axially Swept Light-Sheet Microscopy

The paper introduces a new image acquisition method for light-sheet microscopes that improves spatial context placement and reduces post-processing needs, achieving higher field of view and resolution.

Acute and sub-chronic toxicity of 6PPD-quinone to early-life stage lake trout (Salvelinus namaycush)

This study assesses the acute and sub-chronic toxicity of 6PPD-quinone to early-life stage lake trout, finding significant mortality and deformities at environmentally relevant concentrations.

Does What You Eat Affect How You Mate? Disentangling the Interactions Between Diet-Induced Phenotypic Plasticity and Adult Reproductive Strategies in Black Soldier Flies.

This study examines how larval diets affect adult reproductive strategies and phenotypic plasticity in black soldier flies, revealing sex-specific differences in reproductive investment and mating behaviors.

Construction and application of a technical platform for determining cell cycle- and autophagy-associated cellular accumulation of lipid-based nanoparticles

This study constructs a technical platform to investigate cell cycle- and autophagy-related nanoparticle accumulation, revealing distinct accumulation patterns in specific cell cycle phases.

navigate: an open-source platform for smart light-sheet microscopy.

navigate provides an open-source platform for smart light-sheet microscopy, enabling automated and user-friendly LSFM workflows without requiring specialized expertise.

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

Daily vocalization patterns of the Saipan Reed Warbler (Acrocephalus hiwae)

This study examines the daily vocalization patterns of Saipan Reed Warblers, finding they sing throughout daylight without dawn or evening choruses.

Deciphering the molecular mechanism underlying morphology transition in two-component DNA-protein cophase separation

The paper investigates DNA-protein co-condensates, identifying two morphology transitions and growth dynamics governed by DNA-p53 interaction strength.

Computer simulation and mathematical modeling of the interactions between ecological and sexual selection to reveal the mechanism of sympatric speciation

This paper uses computer simulations and mathematical models to explore how ecological and sexual selection interact to drive sympatric speciation, identifying a five-stage mechanism involving mating-bias alleles and premating reproductive isolation.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Chaperone-mediated autophagy is an overlooked pathway for mutant alpha-1 antitrypsin Z degradation

This study identifies chaperone-mediated autophagy (CMA) as a key pathway for degrading mutant alpha-1 antitrypsin Z (ATZ), showing that enhancing CMA reduces ATZ accumulation in AATD.

Phenology across scales: an intercontinental analysis of leaf-out dates in temperate deciduous tree communities

The paper analyzes leaf-out variability across temperate deciduous forests in North America and Europe, finding similar intra-community variability despite differences in species richness and environmental conditions.

Buffering effects of nonspecifically DNA-bound RNA polymerases in bacteria

This study shows nonspecifically DNA-bound RNA polymerases in bacteria buffer free RNAP concentration, reducing crosstalk between rRNA and mRNA transcription, and are evolutionarily advantageous.

USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase transition potential

This study identifies USP10 as a novel regulator of β-catenin through dual mechanisms involving deubiquitination and phase separation, with implications for cancer treatment.

Dual Ethanolamine Head Groups in Ionizable Lipids Facilitate Phospholipid-free Stable Nanoparticle Formulation for Augmented and Safer mRNA Delivery

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.

MAGIK: A rapid and efficient method to create lineage-specific reporters in human pluripotent stem cells

MAGIK improves knockin efficiency in hPSCs by using modRNAs to insert fluorescent proteins into lineage-specific genes without drug selection or single-cell cloning.

Unraveling the Structure of Meclizine Dihydrochloride with MicroED

This study determines the 3D crystal structure of meclizine dihydrochloride using MicroED and reveals its binding mechanism to the histamine H1 receptor through molecular docking.

Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains

The paper identifies short RNAs that prevent and reverse pathological fibrillization of RNA-binding proteins like FUS and TDP-43, showing therapeutic potential for ALS/FTD.