A new microphysiological system shows hypoxia primes human ISCs for interleukin-dependent rescue of stem cell activity
K. R. Rivera, R. J. Bliton, J. Burclaff, M. J. Czerwinski, J. Liu, J. M. Trueblood, C. Hinesley, K. A. Breau, S. Joshi, V. A. Pozdin, M. Yao, A. L. Ziegler, A. T. Blikslager, M. Daniele, S. Magness
This study uses a microphysiological system to show hypoxia primes human intestinal stem cells (hISCs) to respond to interleukins, enhancing their activity under hypoxic conditions.
bioRxiv · Jan 31, 2023 · PreprintCell Biology