M. Yao

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

Bioadhesive Hydrogel-Coupled and Miniaturized Ultrasound Transducer System for Long-Term, Wearable Neuromodulation

This paper develops a wearable ultrasound device with bioadhesive hydrogel for long-term neuromodulation, demonstrating its effectiveness in suppressing somatosensory responses over 28 days.

CEP44 is required for maintaining centriole duplication and spindle integrity

This study identifies CEP44's role in preventing centriole overduplication and maintaining spindle integrity, linking it to breast carcinoma prognosis.

Discovery of a Novel Chemotype as DYRK1A Inhibitors against Alzheimer's disease: Computational Modeling and Biological Evaluation

This paper identifies a novel DYRK1A inhibitor, compound Q17, through computational screening and validates its efficacy in reducing AD-related pathology in vitro and in vivo.

Multistable mechanosensitive behavior of cell adhesion driven by actomyosin contractility and elastic properties of force-transmitting linkages.

This study develops a model to investigate how molecular heterogeneity in adhesion proteins affects cell adhesion, revealing multistability and feedback loops confirmed experimentally.

In-situ Single-Molecule Investigations of the Impacts of Biochemical Perturbations on Conformational Intermediates of Monomeric α-Synuclein

This study uses in-situ single-molecule techniques to identify a partially folded conformation of α-synuclein and shows its sensitivity to biochemical perturbations and drugs.

Structural basis of EHEP-mediated offense against phlorotannin-induced defense from brown algae to protect akuBGL activity

The paper determines the structures of EHEP and akuBGL to elucidate how EHEP protects akuBGL from phlorotannin inhibition.

The mechanical response of vinculin

This study examines vinculin's mechanical properties, finding it unfolds and refolds in response to force, suggesting it acts as a mechanotransducer.

MORE IS DIFFERENT: DRUG PROPERTY ANALYSIS ON CELLULAR HIGH-CONTENT IMAGES USING DEEP LEARNING

The paper introduces MID, a deep learning method for high-content image analysis that outperforms existing tools in drug toxicity classification and compound identification.

Engrailed-1 Promotes Pancreatic Cancer Metastasis

This study shows EN1 promotes pancreatic cancer metastasis by repressing target genes and enhancing mesenchymal properties.

Plasma cells in human pancreatic ductal adenocarcinoma secrete antibodies to self-antigens

The paper identifies auto-antibodies secreted by plasma cells in PDAC against self-antigens, suggesting a link between chronic inflammation and autoimmunity.

A new microphysiological system shows hypoxia primes human ISCs for interleukin-dependent rescue of stem cell activity

This study uses a microphysiological system to show hypoxia primes human intestinal stem cells (hISCs) to respond to interleukins, enhancing their activity under hypoxic conditions.

A computational model of fractal interface formation in bacterial biofilms

The paper presents a computational model of bacterial biofilm interface formation, showing fractal patterns emerge from cell-level interactions and mechanical forces.

Dynamic interaction of BcsD subunit in type I bacterial cellulose synthase

This study investigates the dynamic interaction of BcsD in type I bacterial cellulose synthase, showing its role in regulating cellulose crystallization through two interaction modes.

The mechanical stability of Tension Gauge Tethers

This study quantifies the tension-dependent lifetime of tension gauge tethers to better understand their mechanical stability under physiological stretching conditions and reinterprets previous experimental observations.

Transcriptome analysis of SARS-CoV-2 naive and recovered individuals vaccinated with inactivated vaccine

The paper analyzes the transcriptome of SARS-CoV-2 naive and recovered individuals vaccinated with inactivated vaccine to understand immune response mechanisms and vaccine effectiveness.

Force-dependent interactions between talin and full-length vinculin

This study investigates how mechanical forces affect talin-vinculin interactions, showing that force exposure of a vinculin binding site relieves vinculin autoinhibition and enhances binding affinity.

Spatial transcriptome sequencing revealed spatial trajectory in the Non-Small Cell Lung Carcinoma

The paper uses spatial transcriptomics to analyze lung cancer heterogeneity, identifying gene expression gradients and tumor subclones, and infers metastasis trajectories through pseudo-time modeling.

Characterization of α2-Adrenergic Receptors Mediated Vasoconstriction in ex vivo model

This study examines vasoconstriction in rat tail lateral veins mediated by α2-adrenergic receptors under different temperatures, finding temperature-dependent differences in contractile responses.

Development of a mini-replicon-based reverse-genetics system for rice stripe tenuivirus

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.

Modified N-linked glycosylation status predicts trafficking defective human Piezo1 channel mutations

The paper shows that N-linked glycosylation in Piezo1 channels is essential for plasma membrane trafficking and that mutations affecting this process are linked to disease.

Mechanosensitive calcium signaling in filopodia

This study shows that stretching forces trigger Ca2+ influx through L-type channels in filopodia, causing persistent Ca2+ oscillations that influence cell migration.

Ultrasound-mediated mechanical forces selectively kill tumor cells

This paper shows low-frequency ultrasound selectively kills tumor cells via a calpain-dependent mitochondrial pathway involving Piezo1 channels, with minimal damage to normal cells in animal models and patient-derived organoids.

Integrative identification by Hi-C revealed distinct advanced structural variations in Lung Adenocarcinoma tissue

This study uses Hi-C to identify structural variations in lung adenocarcinoma tissues, revealing compartment shifts, TADs, and enhancer-promoter loops associated with key genes on chromosome 3.

Reappraisal of Spinach-based RNA Visualization in Plants

This study reevaluates Spinach-based RNA visualization in plants, showing potential for ex vivo and in vivo RNA monitoring.

Pancreatic cancer cells assemble a CXCL12-keratin 19 coating to resist immunotherapy

The paper shows pancreatic cancer cells use transglutaminase-2 to create CXCL12-keratin 19 coatings that block T cells and resist immunotherapy.

Force-dependent recruitment of Piezo1 drives focal adhesion maturation and calcium entry in normal but not tumor cells

The paper shows Piezo1 binds to matrix adhesions in a force-dependent manner in normal cells, promoting adhesion maturation and calcium entry, but not in tumor cells.

Rats Sniff Off Toxic Air

This study shows that rats emit distinct volatile organic compound profiles in their breath when exposed to various airborne toxicants, indicating a potential for using breath analysis to monitor air toxicity.

Fine Sieving of Collected Atmospheric Particles using Oil Electrophoresis (iSCAPE)

The paper introduces iSCAPE, a system that separates atmospheric particles using electrostatic fields and mineral oil, showing different particle mobility and enrichment based on source and charge.

Time- and size-resolved bacterial aerosol dynamics in highly polluted air: new clues for haze formation mechanism

This study investigates time- and size-resolved bacterial aerosol dynamics in highly polluted air, finding that certain bacteria dominate during pollution episodes and may contribute to haze formation.