Author

J. Burclaff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Physiology· 1

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Research Focus:cell type annotation· 6 Organism:human· 5 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Assay:imaging· 2 Assay:scRNA-seq· 2 Approach:deep learning· 1

Frequent Co-Authors

K. A. Breau· 5 shared R. J. Bliton· 4 shared S. T. Magness· 4 shared C. M. Hinesley· 3 shared M. T. Ok· 3 shared A. Zheng· 2 shared I. Gomez-Martinez· 2 shared J. Liu· 2 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersCell Biology

K. A. Breau

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Author profile →

6 papers

Recent·Most cited

Cathartocytosis: Jettisoning of Unwanted Material during Cellular Reprogramming

J. W. Brown, X. Lin, G. A. Nicolazzi, X. Liu, T. Nguyen, M. D. Radyk, J. Burclaff, J. C. Mills

The paper describes a novel lysosome-independent process called cathartocytosis, where cells eject unwanted material during reprogramming, distinct from autophagy.

bioRxiv · Jun 11, 2024 · PreprintCell Biology

An in vitro platform for quantifying cell cycle phase lengths in primary human intestinal stem cells

M. J. Cotton, P. Ariel, K. Chen, V. A. Walcott, M. Dixit, K. A. Breau, C. M. Hinesley, K. Kedziora, C. Y. Tang, A. Zheng, S. T. Magness, J. Burclaff

The paper develops two fluorescent reporter systems and imaging platforms to analyze cell cycle phases in living primary human intestinal stem cells.

bioRxiv · Oct 9, 2023 · PreprintCell Biology

A new microphysiological system shows hypoxia primes human ISCs for interleukin-dependent rescue of stem cell activity

K. R. Rivera, R. J. Bliton, J. Burclaff, M. J. Czerwinski, J. Liu, J. M. Trueblood, C. Hinesley, K. A. Breau, S. Joshi, V. A. Pozdin, M. Yao, A. L. Ziegler, A. T. Blikslager, M. Daniele, S. Magness

This study uses a microphysiological system to show hypoxia primes human intestinal stem cells (hISCs) to respond to interleukins, enhancing their activity under hypoxic conditions.

bioRxiv · Jan 31, 2023 · PreprintCell Biology

SOX9 elongates cell cycle phases and biases fate decisions in human intestinal stem cells

J. Burclaff, R. J. Bliton, K. A. Breau, M. J. Cotton, C. M. Hinesley, M. T. Ok, C. W. Sweet, A. Zheng, E. D. Bankaitis, P. Ariel, S. T. Magness

This study shows SOX9 in human intestinal stem cells slows proliferation, extends G1 phase, and biases differentiation toward specific cell fates.

bioRxiv · Nov 3, 2022 · PreprintCell Biology

A Leaky Human Colon Model Reveals Uncoupled Apical/Basal Cytotoxicity in Early Clostridioides difficile Toxin Exposure

M. T. Ok, J. Liu, R. J. Bliton, C. M. Hinesley, E. E. T. San Pedro, K. A. Breau, I. Gomez-Martinez, J. Burclaff, S. T. Magness

This study develops a human colon model to assess how C. difficile toxins affect epithelial cells from different sides, finding that basal exposure causes more severe toxicity.

bioRxiv · Oct 13, 2022Cell Biology

A proximal-to-distal survey of healthy adult human small intestine and colon epithelium by single-cell transcriptomics

J. Burclaff, R. J. Bliton, K. A. Breau, M. T. Ok, I. Gomez-Martinez, J. S. Ranek, A. P. Bhatt, J. E. Purvis, J. T. Woosley, S. T. Magness

The paper uses single-cell transcriptomics to analyze healthy adult human small intestine and colon epithelium, identifying lineage markers, regional differences, and functional variations across anatomical regions.

bioRxiv · Oct 5, 2021Physiology