Regulatory T-cells in multiple sclerosis produce IL-10 in the central nervous system but are activated by Epstein-Barr Virus
Nadia Pulvirenti, C. Righetti, Francesca Clemente, Barbara Serafini, Chiara Cordiglieri, Chiara Vasco, S. Maioli, Anna Margherita Pietroboni, Eugenia Galeota, Barbara Rosicarelli, Claudia Iannone, Milena Alessandra De Riz, Alejandro Espadas de Arias, Tullia De Feo, Luca V. C. Valenti, , Jens Geginat
This study identifies EOMES+Tr1-like regulatory T-cells in MS that produce IL-10 and are activated by EBV, suggesting their impaired function contributes to immune escape.
bioRxiv · Jul 30, 2024 · PreprintImmunology