Sex-dependent effects of CYP46A1 overexpression on cognitive function during aging
M. Latorre-Leal, P. Rodriguez-Rodriguez, L. Franchini, M. Daniilidou, F. Eroli, B. Winblad, K. Blennow, H. Zetterberg, M. Kivipelto, M. Pacciarini, Y. Wang, W. Griffiths, I. Bjorkhem, A. Sandebring-Matton, P. Merino-Serrais, , S. Maioli
This study shows that CYP46A1 overexpression improves cognitive function in aged female mice but harms male mice, with sex-specific effects on synaptic function and neurodegeneration markers.
bioRxiv · Apr 23, 2021 · PreprintAnimal Behavior & Cognition