Author

S. Manes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Fernandez-Almeida· 1 shared A. Garrido· 1 shared A. Martin· 1 shared A. Ruiz· 1 shared B. Alarcon· 1 shared C. Anerillas· 1 shared C. Drechsler· 1 shared E. Carrasco· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. Fernandez-Almeida

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Author profile →

2 papers

Recent·Most cited

Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis

E. Gabande-Rodriguez, G. Soto-Heredero, E. Carrasco, C. Anerillas, J. I. Escrig-Larena, S. Delgado-Pulido, I. Francos-Quijorna, M. M. Gomez de las Heras, A. Fernandez-Almeida, E. M. Blanco, E. Winand-Osete, V. Zorita, J. Martinez-Cano, A. Garrido, R. de Cabo, , M. Mittelbrunn

This study identifies CD4+ cytotoxic T cells in the bone marrow that enhance granulopoiesis in aged mice, contributing to age-related diseases and showing that CCR5 inhibition can mitigate these effects.

bioRxiv · Jan 26, 2024 · PreprintImmunology

CCR5 deficiency impairs CD4+ T cell memory responses and antigenic sensitivity through increased ceramide synthesis

A. Martin, R. Blanco, J. Casas, M. E. Saez, E. Rodriguez-Bovolenta, I. E. de Rojas, C. Drechsler, L. M. Real, G. Fabrias, A. Ruiz, M. Castro, W. W. A. Schamel, B. Alarcon, H. M. van Santen, S. Manes

This study shows that CCR5 deficiency in CD4+ T cells increases ceramide synthesis, reduces TCR nanoclustering, and impairs memory responses and antigenic sensitivity.

bioRxiv · Feb 14, 2020Immunology