Author

S. McComb

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:fine-mapping· 1

Frequent Co-Authors

D. Bloemberg· 3 shared A. Marcil· 2 shared R. D. Weeratna· 2 shared R. Pon· 2 shared T. Nguyen· 2 shared A. Shepherd· 1 shared B. Bennychen· 1 shared C. Gadoury· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

D. Bloemberg

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Simplified Function-First Method for the Discovery and Optimization of Bispecific Immune Engaging Antibodies

S. McComb, A. Shepherd, B. Bennychen, A. Marcil, D. Bloemberg, R. Pon, R. Weeratna

This paper introduces a high-throughput method for creating and evaluating bispecific T-cell engager antibodies (BITEs) using a simplified function-first approach to identify bioactive molecules without purification.

bioRxiv · Aug 17, 2022Immunology

A small molecule drug screening identifies colistin sulfate as an enhancer of Natural Killer cell cytotoxicity.

S. Cortes-Kaplan, M. Hasim, S. Kaczmarek, Z. Taha, G. Maznyi, S. McComb, S.-H. Lee, J.-S. Diallo, M. Ardolino

The paper screens FDA-approved drugs to find a small molecule that enhances NK cell cytotoxicity against cancer cells.

bioRxiv · Aug 20, 2021 · PreprintImmunology

Antigenic Sensitivity of Membrane-Proximal Targeting Chimeric Antigen Receptors can be Fine-Tuned through Hinge Truncation

S. McComb, T. Nguyen, K. A. Henry, D. Bloemberg, D. Bloemberg, A. Marcil, S. Maclean, R. Gilbert, C. Gadoury, R. Pon, T. Sulea, Q. Zhu, R. D. Weeratna

This study shows that truncating the CD8 hinge domain in CARs can finely tune antigen sensitivity, improving selectivity for tumor cells over healthy ones.

bioRxiv · Oct 30, 2020 · PreprintImmunology

Self-cutting and integrating CRISPR plasmids (SCIPs) enable targeted genomic integration of large genetic payloads for rapid cell engineering

D. Bloemberg, D. Sosa-Miranda, T. Nguyen, R. D. Weeratna, S. McComb

This paper introduces SCIPs, CRISPR plasmids that integrate themselves at targeted genomic sites, enabling efficient and programmable gene editing in mammalian cells.

bioRxiv · Mar 25, 2020Bioengineering