Author

A. Shepherd

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Animal Behavior & Cognition· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 2 Assay:behavioral assay· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. J. Hannan· 1 shared A. M. Zeleznikow-Johnston· 1 shared A. Marcil· 1 shared A. Muppirala· 1 shared A. Obraztsova· 1 shared A. Robinson· 1 shared B. Bennychen· 1 shared B. J. Olson· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperAnimal Behavior & Cognition

A. J. Hannan

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4 papers

Recent·Most cited

A Simplified Function-First Method for the Discovery and Optimization of Bispecific Immune Engaging Antibodies

S. McComb, A. Shepherd, B. Bennychen, A. Marcil, D. Bloemberg, R. Pon, R. Weeratna

This paper introduces a high-throughput method for creating and evaluating bispecific T-cell engager antibodies (BITEs) using a simplified function-first approach to identify bioactive molecules without purification.

bioRxiv · Aug 17, 2022Immunology

RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release from Enteroendocrine Cells

A. Shepherd, L. Feinstein, S. Sabel, D. Rastelli, E. Mezhibovsky, L. Matthews, A. Muppirala, A. Robinson, M. D. Gershon, M. Rao

This study shows RET signaling in the adult intestine limits PYY release from L-cells, which is necessary for normal gut motility in male mice.

bioRxiv · Apr 15, 2022Cell Biology

Progressive impairments in executive function in the APP/PS1 model of Alzheimer’s disease as measured by translatable touchscreen testing

A. Shepherd, J. K. H. Lim, V. H. Y. Wong, A. M. Zeleznikow-Johnston, L. Churilov, C. T. O. Nguyen, B. V. Bui, A. J. Hannan, E. L. Burrows

The paper assesses executive function in APP/PS1 mice using touchscreen tasks and finds age-related deficits in extinction and reversal, independent of visual impairments.

bioRxiv · Aug 21, 2019Animal Behavior & Cognition

sumrep: a summary statistic framework for immune receptor repertoire comparison and model validation

B. J. Olson, P. Moghimi, C. Schramm, A. Obraztsova, D. Ralph, J. A. Vander Heiden, M. Shugay, A. Shepherd, W. Lees, F. A. Matsen

sumrep is an R package for analyzing and comparing immune receptor repertoires, showing that recombination features are more discriminative than amino acid composition summaries and that generative models capture some but not all repertoire properties.

bioRxiv · Aug 6, 2019Immunology