Branched photoswitchable tethered ligands enable ultra-efficient optical control and detection of class C G protein-coupled receptors
A. Acosta-Ruiz, V. A. Gutzeit, M. J. Skelly, S. Meadows, J. Lee, A. G. Orr, K. Pleil, J. Broichhagen, J. Levitz
This paper develops branched photoswitchable ligands for efficient optical control and detection of class C G protein-coupled receptors, demonstrating near-complete agonism and dual imaging/manipulation capabilities.
bioRxiv · Feb 28, 2019Bioengineering