BioengineeringbioRxiv
Branched photoswitchable tethered ligands enable ultra-efficient optical control and detection of class C G protein-coupled receptors
A. Acosta-Ruiz, V. A. Gutzeit, M. J. Skelly…·J. Levitz
This paper develops branched photoswitchable ligands for efficient optical control and detection of class C G protein-coupled receptors, demonstrating near-complete agonism and dual imaging/manipulation capabilities.
DOI 10.1016/j.neuron.2019.10.036