Interfering with MIF-CD74 signalling on macrophages and dendritic cells with a peptide-based approach restores the immune response against metastatic melanoma.
C. R. Figueiredo, R. A. Azevedo, S. Mousdell, P. T. Resende-Lara, L. Ireland, A. Santos, N. Girola, R. L. O. R. Cunha, M. Schmid, L. Polonelli, L. R. Travassos, A. Mielgo
This study shows that a peptide-based therapy targeting the MIF-CD74 pathway in macrophages and dendritic cells can restore anti-tumour immunity in metastatic melanoma.
bioRxiv · Jan 16, 2018Cancer Biology