M. Schmid

The evolution of local adaptation in long-lived species

This study shows that life history traits influence local adaptation in long-lived species depending on the timing of selection and dispersal events.

The Arabidopsis thaliana core splicing factor PORCUPINE/SmE1 requires intron-mediated expression

The paper investigates the phylogeny and differential regulation of SmE-coding genes in Arabidopsis thaliana, showing functional conservation and transcriptional regulation differences between PCP and PCPL.

The Arabidopsis splicing factor PORCUPINE/SmE1 orchestrates temperature-dependent root development via auxin homeostasis maintenance

This study shows that the splicing factor PORCUPINE regulates temperature-dependent root development in Arabidopsis by maintaining auxin homeostasis in the root apical meristem.

Mutations in HUA2 restore flowering in the Arabidopsis trehalose 6-phosphate synthase1 (tps1) mutant

This study identifies HUA2 mutations that restore flowering and embryogenesis in the tps1-2 GVG::TPS1 Arabidopsis mutant by modulating carbohydrate signaling and activating flowering regulators.

Methylosome and SMN complexes are dispensable for snRNP assembly in Arabidopsis

This study investigates the role of methylosome and SMN complexes in snRNP assembly in Arabidopsis under temperature changes, finding that these complexes have a less crucial role than previously thought.

Arabidopsis thaliana LSM7 is essential for auxin-mediated regulation of SAUR genes and thermomorphogenesis

This study shows that LSM7 is essential for auxin-mediated regulation of SAUR genes and thermomorphogenesis in Arabidopsis thaliana under high temperatures.

Foraging for locally and spatially varying resources: Where exploitation competition, local adaptation and kin selection meet

The paper uses mathematical modeling to show that locally and spatially disruptive selection often act together to promote polymorphism in consumer populations, but kin competition can inhibit this under limited dispersal.

PICLN modulates alternative splicing and ensures adaptation to light and temperature changes in plants

This study shows PICLN modulates alternative splicing and helps plants adapt to light and temperature changes by interacting with the methylosome complex and GEMIN2.

Human iPSC-CMs and in-silico technologies define mechanisms and accelerate targeted pharmacogenetics in hypertrophic cardiomyopathy

The paper combines human iPSC-CMs and in-silico models to identify genotype-specific pathomechanisms and therapeutic targets in hypertrophic cardiomyopathy.

Proteins released into the plant apoplast by the obligate parasitic protist Albugo selectively repress phyllosphere-associated bacteria

The paper identifies three Albugo proteins that selectively inhibit gram-positive bacteria in the phyllosphere, suggesting their potential as biocontrol agents.

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

This study shows that hybrid immunity and vaccine boosters provide potent neutralizing activity against Omicron BA.1 and BA.2, while breakthrough infections induce nasal mucosal neutralization and identify an ultrapotent pan-variant antibody.

Perception of a conserved family of plant signalling peptides by the receptor kinase HSL3

The paper identifies CTNIPs as a conserved family of plant signaling peptides and shows that HSL3 is their receptor, revealing an ancient signaling module involved in stress responses.

Adaptive anti-tumor immunity is orchestrated by a population of CCL5-producing tissue-resident NK cells

The paper shows that CCL5-producing tissue-resident NK cells are critical for IL-12-mediated anti-tumor immunity and that CCL5 delivery can overcome resistance in tumors with low trNK cell infiltration.

Histone H3 Clipping is a novel signature of Human Neutrophil Extracellular Traps

This study identifies a histone H3 cleavage event specific to neutrophil extracellular traps (NETs) and develops an antibody to detect and quantify NETs in various samples.

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

This paper evaluates the in vitro and in vivo efficacy of dual-action monoclonal antibodies VIR-7831 and VIR-7832 against SARS-CoV-2, showing potent neutralization and reduced viral load in a hamster model.

Integrator is a genome-wide attenuator of non-productive transcription

The paper identifies genome-wide roles of the Integrator complex in attenuating non-productive transcription by dampening weak promoters and quality-controlling RNAPII complexes.

A tradeoff between robustness to environmental fluctuations and speed of evolution

This study shows a tradeoff between robustness to environmental fluctuations and speed of evolution in life histories.

Conifers exhibit a characteristic inactivation of auxin to maintain tissue homeostasis

The paper investigates IAA inactivation pathways in conifers, finding that oxidative and conjugative pathways differ in their contribution to auxin homeostasis compared to Arabidopsis.

A bacterial assay for rapid screening of IAA catabolic enzymes

This paper introduces a bacterial assay to rapidly screen IAA catabolic enzymes by measuring enzymatic products directly from bacterial cultures without protein purification.

High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

Effects of FLOWERING LOCUS T on FD during the transition to flowering at the shoot apical meristem of Arabidopsis thaliana

This study identifies FD's genome-wide transcriptional targets and shows its role beyond flowering regulation in Arabidopsis thaliana.

ADP heptose, a novel pathogen-associated molecular pattern associated with Helicobacter pylori type 4 secretion

The paper identifies ADP heptose as the key PAMP in Helicobacter pylori that activates NF-κB via the Alpk1-TIFA axis, showing 100-fold stronger activity than previously proposed HBP.

Species’ range dynamics affect the evolution of spatial variation in plasticity under environmental change

This study uses individual-based simulations to show how environmental range dynamics influence the evolution of spatial variation in tolerance and plasticity across species ranges under different environmental change scenarios.

Interfering with MIF-CD74 signalling on macrophages and dendritic cells with a peptide-based approach restores the immune response against metastatic melanoma.

This study shows that a peptide-based therapy targeting the MIF-CD74 pathway in macrophages and dendritic cells can restore anti-tumour immunity in metastatic melanoma.

Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer

This study shows that macrophage-derived granulin promotes resistance to immune checkpoint inhibitors in metastatic pancreatic cancer by excluding CD8+ T cells, and blocking granulin improves anti-tumor immunity.

Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer.

This study shows that blocking insulin-like growth factors enhances paclitaxel's effectiveness against metastatic breast cancer by reducing tumor growth and lung metastasis in pre-clinical models.