mTOR S-nitrosylation inhibits autophagy and lysosomal proteolysis
B. W. Q. Tan, S. Tan, B. W. L. Tan, S. Navakkode, C. Y. Ng, S. Yuan, M. C. Liang, C. Liu, S. Yin, C. Chai, K. C. M. Chew, Y. K. Tai, S. Sreedharan, Y. Lam, P. Liao, , T. W. Soong
This study identifies mTOR S-nitrosylation as a kinase-independent mechanism that suppresses autophagy and lysosomal proteolysis, with implications for Alzheimer's disease.
bioRxiv · Sep 11, 2020 · PreprintCell Biology