S. Tan

Adipokinetic hormone signaling mediates the enhanced fecundity of Diaphorina citri infected by 'Candidatus Liberibacter asiaticus'

This study identifies adipokinetic hormone signaling as a key mediator of increased fecundity in CLas-infected D. citri, revealing a mutualistic interaction between the bacterium and the insect.

Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremia

This study identifies HXA3 as a driver of neutrophil transmigration and elastase release during pneumococcal infection, showing that blocking these processes reduces epithelial damage and bacteremia.

EZ-SPOTs: A simple and robust high-throughput liquid handling platform

EZ-SPOTs provides a cost-effective, reusable liquid handling platform for high-throughput experiments, matching gold standard assays in antibiotic susceptibility testing.

The iAAA-mitochondrial protease YME1L1 regulates the degradation of the short-lived mitochondrial transporter SLC25A38

The paper identifies SLC25A38 as a short-lived mitochondrial transporter degraded by YME1L1 and shows its degradation is regulated by mitochondrial membrane potential.

Microbial community assembly during aging of food waste-derived hydrochar: key bacterial guilds mediate nutrient dynamics

This study investigates how adding straw and microbes accelerates hydrochar aging by identifying key bacterial guilds involved in nutrient cycling.

SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation to suppress excessive bacterial inflammation

This study shows SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation, thereby suppressing bacterial inflammation in Chinese tongue sole.

Surface Patterned Omniphobic Tiles (SPOTs): a versatile platform for scalable liquid handling

The paper introduces SPOTs, a low-cost, scalable platform for liquid handling that enables high-throughput experiments with precision and compatibility with existing lab equipment.

De novo design of drug-binding proteins with predictable binding energy and specificity

This paper designs drug-binding proteins with low nanomolar affinity and predictable specificity using computational methods, validated by experimental measurements and structural analysis.

Preclinical evaluation of RQ3013, a broad-spectrum mRNA vaccine against SARS-CoV-2 variants

This paper evaluates RQ3013, an mRNA vaccine against SARS-CoV-2 variants, showing robust immune responses and protection in animal models.

Platelet-specific TGFβ1 deficiency aggravates atherosclerosis, vascular inflammation, and hypercholesterolemia in mice

Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lung

This study identifies aberrant macrophage activation and maladaptive lung repair as key factors promoting tuberculosis progression in the lung using a novel mouse model.

Dual Ethanolamine Head Groups in Ionizable Lipids Facilitate Phospholipid-free Stable Nanoparticle Formulation for Augmented and Safer mRNA Delivery

This paper introduces ionizable lipids with dual ethanolamine head groups for phospholipid-free mRNA delivery, showing improved stability, efficiency, and reduced toxicity.

The beta 6 Integrin Negatively Regulates TLR7-Mediated Epithelial Immunity via Autophagy During Influenza A Virus Infection

This study shows that beta 6 integrin suppresses TLR7-mediated epithelial immunity during influenza A virus infection by promoting autophagy and altering TLR7 trafficking.

Mycobacterium tuberculosis response to cholesterol is integrated with environmental pH and potassium levels via a lipid utilization regulator

The paper shows that Mtb's response to cholesterol, pH, and potassium is coordinated via the Mce3R regulator, with mce3R deletion reducing colonization in mice.

Pore-forming activity of S. pneumoniae pneumolysin disrupts the paracellular localization of the epithelial adherens junction protein E-cadherin

This study shows that pneumolysin from S. pneumoniae disrupts E-cadherin localization through PLY-dependent and -independent mechanisms, but maximal bacterial translocation requires PLY-dependent neutrophil recruitment.

Astrovirus replication is dependent on induction of double membrane vesicles through a PI3K-dependent, LC3-independent pathway

This study shows astrovirus replication depends on PI3K-dependent, LC3-independent DMV formation, suggesting PI3K as a therapeutic target for viral infections.

Periostin facilitates ovarian cancer recurrence by enhancing cancer stemness

This study shows that periostin promotes ovarian cancer recurrence by enhancing cancer stemness and chemoresistance through TME interactions.

Cryo-EM structure of the human Sirtuin 6-nucleosome complex

The paper presents the cryo-EM structure of the human SIRT6-nucleosome complex, revealing how SIRT6 deacetylates histone H3 K9 and K56.

Atlas-Guided Discovery of Transcription Factors for T Cell Programming

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

ABP1/ABL3-TMK1 cell-surface auxin signaling directly targets PIN2-mediated auxin fluxes for root gravitropism

The paper identifies a mechanism where auxin signaling via ABP1-TMK1 receptor module stabilizes PIN2 to reinforce asymmetric auxin flow for root gravitropism.

Chemical inhibition of PIN auxin transporters by the anti-inflammatory drug Naproxen

This study identifies Naproxen as a chemical inhibitor of PIN auxin transporters in plants, revealing its mechanism of action through cellular, biochemical, and structural analyses.

Diversity and Evolution of Computationally Predicted T Cell Epitopes against Human Respiratory Syncytial Virus

This study computationally predicts T cell epitopes in RSV proteins and finds divergent epitope patterns between RSV-A and RSV-B strains, suggesting vaccine updates may be needed for RSV-B.

De novo design of site-specific protein interactions with learned surface fingerprints

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

PrrA modulates Mycobacterium tuberculosis response to multiple environmental cues and is critically regulated by serine/threonine protein kinases

This study identifies PrrA as a key transcription factor modulating Mycobacterium tuberculosis response to environmental cues, revealing its regulation by serine/threonine protein kinases.

Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome depleted regions

This study shows how Cbf1's HLH region interacts with histones to slow nucleosome dissociation, enabling chromatin opening.

CLE42 Delays Leaf Senescence by Antagonizing Ethylene Pathway in Arabidopsis

This study identifies CLE42 as a negative regulator of leaf senescence in Arabidopsis, showing it delays senescence by suppressing the ethylene pathway.

Improved immunoassay sensitivity and specificity using single-molecule colocalization

The paper introduces SiMCA, a method using TIRF microscopy to improve immunoassay sensitivity and specificity by eliminating non-specific background through colocalization of fluorescent signals.

Dual engagement of the nucleosomal acidic patches is essential for deposition of histone H2A.Z by SWR1C

This study shows that SWR1C requires both nucleosomal acidic patches for H2A.Z deposition, revealing a 'pincer-like' engagement mechanism and a conserved arginine-rich motif in Swc5.

Serum Amyloid A promotes Acetaminophen-induced liverinjury by damaging sinusoidal endothelial cell and exacerbating platelet aggregation in liver

This study shows that Serum Amyloid A (SAA) worsens acetaminophen-induced liver injury by damaging sinusoidal endothelial cells and increasing platelet aggregation.

Spatial relationships of intra-lesion heterogeneity in Mycobacterium tuberculosis microenvironment, replication status, and drug efficacy

This study examines spatial heterogeneity in Mtb microenvironment, replication, and drug efficacy using in situ imaging in a murine model.