Anoctamin-1 is induced by TGF-beta and contributes to lung myofibroblast differentiation
E. B. Reed, S. Orbeta, B. A. Miao, A. Sitikov, B. Chen, I. Levitan, J. Solway, G. M. Mutlu, Y. Fang, A. A. Mongin, N. O. Dulin
This study shows TGF-beta induces ANO1 in lung fibroblasts, which increases intracellular chloride and activates WNK1 to promote myofibroblast differentiation and fibrosis.
bioRxiv · Jun 7, 2023Cell Biology