Author

G. M. Mutlu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Y. Meliton· 3 shared B. Chen· 2 shared K. A. Sun· 2 shared O. R. Shamaa· 2 shared P. S. Woods· 2 shared R. B. Hamanaka· 2 shared R. Cetin-Atalay· 2 shared Y. Fang· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCell Biology

A. Y. Meliton

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mitochondrial One-Carbon Metabolism is Required for TGF-β-Induced Glycine Synthesis and Collagen Protein Production

A. Y. Meliton, R. Cetin-Atalay, Y. Tian, J. C. Szafran, K. W. D. Shin, T. Cho, K. A. Sun, P. S. Woods, O. R. Shamaa, B. Chen, A. Muir, G. M. Mutlu, R. B. Hamanaka

This study shows that mitochondrial one-carbon metabolism is essential for TGF-β-induced glycine synthesis and collagen production in lung fibroblasts, suggesting MTHFD2 inhibitors could treat IPF.

bioRxiv · Nov 7, 2023Cell Biology

Anoctamin-1 is induced by TGF-beta and contributes to lung myofibroblast differentiation

E. B. Reed, S. Orbeta, B. A. Miao, A. Sitikov, B. Chen, I. Levitan, J. Solway, G. M. Mutlu, Y. Fang, A. A. Mongin, N. O. Dulin

This study shows TGF-beta induces ANO1 in lung fibroblasts, which increases intracellular chloride and activates WNK1 to promote myofibroblast differentiation and fibrosis.

bioRxiv · Jun 7, 2023Cell Biology

HIF-1α induces glycolytic reprogramming in tissue-resident alveolar macrophagesto promote survival during acute lung injury

P. S. Woods, L. M. Kimmig, K. A. Sun, A. Y. Meliton, O. R. Shamaa, Y. Tian, R. Cetin-Atalay, W. W. Sharp, R. B. Hamanaka, G. M. Mutlu

This study shows hypoxia stabilizes HIF-1α in alveolar macrophages, promoting glycolytic reprogramming that enhances survival during acute lung injury.

bioRxiv · Feb 28, 2022Cell Biology

SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy

T.-H. Lee, D. Wu, R. Guzy, N. Schoettler, A. Adegunsoye, J. Mueller, A. Hussein, A. Sperling, G. M. Mutlu, Y. Fang

This study shows that SARS-CoV-2 infection reduces KLF2 in human lung autopsies, linking KLF2 down-regulation to vascular dysfunction in ARDS.

bioRxiv · Jan 15, 2021 · PreprintPathology

The Aging Microenvironment Shapes Alveolar Macrophage Identity in Aging

A. C. McQuattie-Pimentel, Z. Ren, N. Joshi, S. Watanabe, T. Stoeger, M. Chi, Z. Lu, L. Sichizya, R. Piseaux, C.-I. Chen, S. Soberanes, P. A. Reyfman, J. M. Walter, K. R. Anekalla, J. M. Davis, , G. S. Budinger

This study shows that the aging lung microenvironment shapes alveolar macrophage identity, influencing their phenotype during aging and after injury.

bioRxiv · Jul 29, 2019 · PreprintImmunology