Three-dimensional interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis
I. J. Groves, E. L. Drane, M. Michalski, J. M. Monahan, C. G. Scarpini, S. P. Smith, G. Bussotti, C. Varnai, S. Schoenfelder, P. Fraser, A. J. Enright, N. Coleman
This study shows HPV integration disrupts host gene expression by altering 3D chromatin interactions, revealing a mechanism for early cervical cancer development.
bioRxiv · Feb 3, 2021Cancer Biology