Author

P. Fraser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Assay:ChIP-seq· 2 Assay:Hi-C· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

C. Varnai· 2 shared S. Schoenfelder· 2 shared A. Bruzas· 1 shared A. C. Lewis· 1 shared A. Dimond· 1 shared A. E. Tron· 1 shared A. J. Enright· 1 shared A. J. Rogers· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCancer Biology

C. Varnai

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells

E. Gruber, J. So, A. C. Lewis, R. Franich, R. Cole, L. G. Martelotto, A. J. Rogers, E. Vidacs, P. Fraser, K. Stanley, L. Jones, A. S. Trigos, N. Thio, J. Li, B. Nicolay, , L. M. Kats

This study shows that inhibiting mutant IDH1 in AML promotes leukemic stem cell cycling and sensitizes the disease to azacitidine, suggesting a combination therapy approach.

bioRxiv · Apr 6, 2022Cancer Biology

Three-dimensional interactions between integrated HPV genomes and cellular chromatin dysregulate host gene expression in early cervical carcinogenesis

I. J. Groves, E. L. Drane, M. Michalski, J. M. Monahan, C. G. Scarpini, S. P. Smith, G. Bussotti, C. Varnai, S. Schoenfelder, P. Fraser, A. J. Enright, N. Coleman

This study shows HPV integration disrupts host gene expression by altering 3D chromatin interactions, revealing a mechanism for early cervical cancer development.

bioRxiv · Feb 3, 2021Cancer Biology

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, while the Alzheimer's R47H mutant does the opposite

A. Vilalta, Y. Zhou, J. Sevalle, J. K. Griffin, K. Sato, D. H. Allendorf, S. De, M. Puigdellivol, A. Bruzas, M. A. Burguillos, R. B. Dodd, F. Chen, Y. Zhang, P. Flagmeier, L.-M. Needham, , G. C. Brown

The paper shows wild-type sTREM2 inhibits Aβ aggregation and neurotoxicity, while the R47H variant promotes Aβ aggregation and neurotoxicity.

bioRxiv · Dec 3, 2020Biochemistry

ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL

G. Wutz, B. T. G. St. Hilaire, R. Ladurner, R. Stocsits, K. Nagasaka, B. Pignard, A. Sanborn, W. Tang, C. Varnai, M. Ivanov, S. Schoenfelder, P. van der Lelij, X. Huang, G. Duernberger, E. Roitinger, , J. M. Peters

The paper shows that ESCO1 and CTCF protect cohesinSTAG1 from WAPL, enabling long chromatin loops that persist during G1-phase.

bioRxiv · Sep 23, 2019Cell Biology

Allele-specific control of replication timing and genome organization during development

J. C. Rivera-Mulia, A. Dimond, D. Vera, C. Trevilla-Garcia, T. Sasaki, J. Zimmerman, C. Dupont, J. Gribnau, P. Fraser, D. M. Gilbert

This study identifies allele-specific replication timing and genome organization differences in hybrid mouse embryos and shows they diminish during differentiation.

bioRxiv · Nov 21, 2017Cell Biology