Author

S. Parween

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Approach:deep learning· 1 Organism:plant (other)· 1

Frequent Co-Authors

A. V. Pandey· 5 shared P. R. Castano· 2 shared S. S. Udhane· 2 shared A. Poon· 1 shared B. Hardy· 1 shared B. L. Moller· 1 shared B. Lopez· 1 shared C. Boglari· 1 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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5 shared papersPharmacology & Toxicology

A. V. Pandey

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Author profile →

6 papers

Recent·Most cited

Skin Sensitisation Case Study: Comparison of Defined Approaches including OECD 497 Guidance

B. Hardy, P. Ankli, S. Parween, B. Lopez, P. Daligaux, T. Mohoric, T. Darde, C. Chesne, N. Stockman, C. Boglari, A. Poon

The paper compares different defined approaches for skin sensitisation assessment, including OECD guidance and emerging methods, to evaluate their effectiveness in characterising chemical compounds.

bioRxiv · Feb 12, 2024 · PreprintPharmacology & Toxicology

Across kingdom biased CYP-mediated metabolism via small-molecule ligands docking on P450 oxidoreductase

S. B. Jensen, S. Thodberg, S. Parween, M. E. Moses, C. C. Hansen, J. Thomsen, M. B. Sletfjerding, C. Knudsen, R. D. Giudice, P. M. Lund, P. R. Castano, Y. G. Bustamante, F. S. Jorgensen, A. V. Pandey, T. Laursen, , N. S. Hatzakis

The paper identifies ligands that dock on P450 oxidoreductase (POR) to bias its specificity towards CYP redox partners, revealing a mechanism for pathway-specific metabolism.

bioRxiv · Sep 23, 2020 · PreprintBiophysics

Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H

S. Parween, G. Di Nardo, F. Baj, C. Zhang, G. Gilardi, A. V. Pandey

This study investigates how variations in P450 oxidoreductase (POR) affect the aromatase activity of CYP19A1 polymorphisms R264C and R264H, showing differential impacts based on POR variants.

bioRxiv · Oct 22, 2019Biochemistry

Bioactivity of curcumin on the cytochrome P450 enzymes of the steroidogenic pathways

P. R. Castano, S. Parween, A. V. Pandey

This study investigates the effects of curcuminoids on cytochrome P450 enzymes involved in steroid metabolism, finding significant inhibition of CYP17A1 and CYP19A1 activities.

bioRxiv · Aug 7, 2019Pharmacology & Toxicology

Loss of multiple enzyme activities due to the human genetic variation P284T in NADPH cytochrome P450 oxidoreductase

S. Parween, M. N. R. Velazquez, S. S. Udhane, N. Kagawa, A. V. Pandey

This study investigates the impact of the P284T variant in POR on cytochrome P450 enzyme activities, finding significant reductions in several key functions.

bioRxiv · May 20, 2019Pharmacology & Toxicology

Variability in Human Drug Metabolizing Cytochrome P450 CYP2C9, CYP2C19 and CYP3A5 Activities Caused by Genetic Variations in Cytochrome P450 Oxidoreductase

M. N. R. Velazques, S. Parween, S. S. Udhane, A. V. Pandey

This study identifies POR variants affecting CYP2C9, CYP2C19, and CYP3A5 activities and shows their impact on drug metabolism.

bioRxiv · May 17, 2019Pharmacology & Toxicology