Author

S. Paschkowsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Animal Behavior & Cognition· 1 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

L. M. Munter· 2 shared S. J. Recinto· 2 shared Y. C. M. Penalva· 2 shared A. Duchesne· 1 shared A. Nitu· 1 shared B. Michalski· 1 shared B. Xiao· 1 shared C. Levet· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersAnimal Behavior & Cognition

L. M. Munter

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2 papers

Recent·Most cited

Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer's disease mouse model.

Y. C. M. Penalva, S. Paschkowsky, J. Yang, S. J. Recinto, J. Cinkorpumin, M. Ruelas Hernandez, B. Xiao, A. Nitu, H. Y.-L. Wu, H. M. Munter, B. Michalski, M. Fahnestock, W. A. Pastor, D. A. Bennett, L. M. Munter

This study shows that loss of RHBDL4 in Alzheimer's disease mice increases APP and rescues cognition by reducing proteasomal degradation of β-catenin.

bioRxiv · Feb 22, 2024Animal Behavior & Cognition

Eta-secretase-like processing of the amyloid precursor protein (APP) by RHBDL4

Y. C. M. Penalva, S. Paschkowsky, S. J. Recinto, A. Duchesne, C. Levet, F. Charron, M. Freeman, R. A. McKinney, J.-F. Trempe, L. M. Munter

This study identifies RHBDL4 as an enzyme that processes APP similarly to {eta}-secretase, generating A{eta}-like fragments in the ER without requiring other proteases.

bioRxiv · Sep 4, 2023 · PreprintBiochemistry