Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.
R. Kudira, Z. F. Yang, I. Osuji, R. Karns, P. Bariya, L. Pfuhler, M. Mullen, A. Taylor, H. Ji, C. S. Lages, A. Yang vom Hofe, T. Shi, S. Pasula, J. A. Wayman, A. Bernieh, , A. G. Miethke
This study shows cholestasis shifts hepatic Tregs to a Th17 phenotype and impairs their suppressor function, with bile acid levels influencing Treg activity and liver injury.
bioRxiv · May 17, 2024 · PreprintImmunology