A. Taylor

Quantifying evidence for phenotypic specificity (PP4) for syndromic phenotypes: Large-scale integration of rare germline FH variants from diagnostic laboratory testing for HLRCC (Hereditary Leiomyomatosis and Renal Cell Cancer) and renal cancer

The paper quantifies phenotypic specificity of rare FH variants in HLRCC and renal cancer using likelihood ratios from clinical and population data.

Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)

The paper develops a framework for classifying variants of reduced penetrance in cancer susceptibility genes to improve variant interpretation consistency.

Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.

This study shows cholestasis shifts hepatic Tregs to a Th17 phenotype and impairs their suppressor function, with bile acid levels influencing Treg activity and liver injury.

Sounds of the underground reflect soil biodiversity dynamics across a grassy woodland restoration chronosequence

The paper uses ecoacoustics to measure soil biodiversity in a restoration chronosequence, finding higher acoustic complexity and diversity in revegetated and remnant plots compared to cleared plots.

Mechanistic implications of the ternary complex structural models for the photoenzyme protochlorophyllide oxidoreductase.

The paper investigates structural models of the POR-Pchlide-NADPH ternary complex and proposes an alternative model based on mutagenesis and computational analysis, identifying key residues involved in catalysis.

Mesothelial cells exhibit characteristics of perivascular cells in an in vitro angiogenesis assay

This study shows mesothelial cells can adopt a perivascular phenotype and support angiogenesis in vitro by aligning with endothelial networks and upregulating pericyte markers.

The contribution of plant life and growth forms to global gradients of vascular plant diversity

The paper quantifies how different plant forms contribute to global vascular plant diversity gradients and identifies environmental and phylogenetic factors shaping their distribution.

Near infrared conjugated polymer nanoparticles (CPN) for tracking cells using fluorescence and optoacoustic imaging

This study develops near-infrared conjugated polymer nanoparticles (CPNs) for cell tracking using fluorescence and optoacoustic imaging, showing they outperform indocyanine green (ICG) in some applications.

Phylogenetic endemism of the world's seed plants

This study quantifies phylogenetic endemism in seed plants worldwide, identifying drivers and centers of neo- and paleoendemism, and highlights conservation priorities.

Multicentre comparison of biological and functional properties of mesenchymal stromal cells from different sources cultivated using a harmonised manufacturing workflow

This study compares MSC characteristics across three tissue sources using harmonised culture conditions, finding reproducible results and source-specific functional differences.

Computed tomography lacks sensitivity to image gold labelled mesenchymal stromal cells in vivo as evidenced by multispectral optoacoustic tomography.

The paper compares imaging modalities for tracking gold-labelled mesenchymal stromal cells in vivo, finding that CT lacks sensitivity compared to BLI and MSOT.

Simplified fecal community transplant restores Clostridioides difficile colonization resistance to antibiotic perturbed murine communities

This study shows that a simplified fecal community transplant can restore colonization resistance to antibiotic-perturbed murine gut communities, preventing Clostridioides difficile colonization depending on the community structure.

Climate and ant richness explain the global distribution of ant-plant mutualisms

This study examines how climate and ant richness influence the global distribution of three ant-plant mutualisms, revealing distinct biogeographic patterns and climate dependencies.

Actin nano-architecture of phagocytic podosomes

The paper uses advanced microscopy techniques to characterize the structure of phagocytic podosomes during frustrated phagocytosis, revealing their unique actin architecture and associated protein distributions.

Machine learning improves global models of plant diversity

The paper uses machine learning and statistical models to predict global plant diversity patterns based on environmental data, achieving high accuracy for species and phylogenetic richness.

Identification of genetic loci in lettuce mediating quantitative resistance to fungal pathogens

The paper identifies genetic loci in lettuce conferring quantitative resistance to fungal pathogens and predicts molecular mechanisms through transcriptome profiling.

Development of an in-situ printing system with human platelet lysate-based bio-adhesive to treat corneal perforation

This paper develops an in-situ printing system using a human platelet lysate-based bio-adhesive to treat corneal perforations, showing improved adhesion, burst pressure, and faster healing in rabbits compared to cyanoacrylate glue.

Drought stress increases the expression of barley defence genes with negative consequences for infesting cereal aphids

This study shows drought stress increases barley defense gene expression, which negatively affects cereal aphid fitness and population dynamics.

An osmotic laxative renders mice susceptible to prolonged Clostridioides difficile colonization and hinders clearance

This study shows that PEG laxative treatment in mice increases susceptibility to C. difficile colonization and delays clearance.

Norepinephrine activates β1-adrenergic receptors localized to the inner nuclear membrane in cortical astrocytes

This study shows that β1-adrenergic receptors in astrocytes are located in the inner nuclear membrane and respond to norepinephrine via transporter-mediated uptake, activating Gs signaling and PKA.

Vascular epiphytes contribute disproportionately to global centres of plant diversity

This study quantifies the contribution of vascular epiphytes to global plant diversity and identifies environmental drivers shaping their distribution.

Mycena species can be opportunist-generalist plant root invaders

The paper investigates Mycena species' role as plant root invaders using metabarcoding and stable isotope analysis, finding they opportunistically invade roots and may occupy different ecological roles.

The novel roles of choline transporter-like 1 and 2 in ethanolamine transport

This paper identifies CTL1 and CTL2 as ethanolamine transporters in mammalian cells and mitochondria, showing their roles in PE synthesis and linking their dysfunction to neurodegenerative and autoimmune diseases.

A novel single-domain Na+-selective voltage-gated channel in photosynthetic eukaryotes

The paper identifies a novel class of Na+-selective single-domain voltage-gated channels in haptophyte algae, demonstrating rapid Na+-based signaling in photosynthetic eukaryotes.

RNA-seq of Human T-Cells After Hematopoietic Stem Cell Transplantation Identifies Linc00402 as a Novel Regulator of T-Cell Alloimmunity

The paper identifies Linc00402 as a novel lncRNA regulating allogeneic T-cell responses through RNA-seq analysis of human T-cells post-HSCT.

Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis

This study identifies key transcriptional pathways in IPF fibroblastic foci using RNA-seq and bioinformatics, highlighting the TSC2/RHEB axis as a potential therapeutic target for fibrosis.

The role of CAPG in molecular communication between the embryo and the uterine endometrium: Is its function conserved in species with different implantation strategies?

This study shows that CAPG, a conserved protein, induces transcriptional changes in endometrial cells of humans and cattle, potentially aiding implantation across species with different implantation strategies.

Generation of twenty four induced pluripotent stem cell lines from twenty four members of the Lothian Birth Cohort 1936

The paper generates 24 induced pluripotent stem cell lines from members of the Lothian Birth Cohort 1936 to study cognitive ageing and neurodegenerative disease resilience.

CD99 regulates cancer cell transendothelial migration and endothelial cell function via CDC42 and actin remodelling

This study shows CD99 regulates cancer cell transendothelial migration and endothelial function through CDC42 and actin remodeling in breast and prostate cancer.

Disharmony of the world’s island floras

The paper quantitatively assesses island disharmony by analyzing 320 island floras and 450 plant families, finding compositional bias linked to island characteristics rather than family traits.