T. Shi

A fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis

This paper introduces a fast and sensitive size-exclusion chromatography method for plasma extracellular vesicle proteomic analysis, demonstrating its utility in identifying EV proteins related to physical activity.

Cholestasis alters polarization and suppressor function of hepatic regulatory T cells.

This study shows cholestasis shifts hepatic Tregs to a Th17 phenotype and impairs their suppressor function, with bile acid levels influencing Treg activity and liver injury.

Stimulative piezoelectric nanofibrous scaffolds for enhanced small extracellular vesicle production in 3D cultures

This paper develops a 3D culture platform using piezoelectric nanofibrous scaffolds with acoustic stimulation to significantly enhance small extracellular vesicle production.

A Mem-dELISA platform for dual color and ultrasensitive digital detection of colocalized proteins on extracellular vesicles

The paper introduces a Mem-dELISA platform for ultrasensitive, dual-color detection of colocalized proteins on extracellular vesicles, demonstrating its application in cancer research.

Unveiling the Intricate Sinking behavior of Large Diatoms: Insights from Time-Frequency Analysis of Palmerina hardmaniana Sinking under Silicate-Depleted Conditions

This study uses wavelet analysis to examine how silicate depletion affects the sinking behavior of Palmerina hardmaniana, revealing intermittent regulation with similar frequency ranges in control and stressed conditions.

Camel milk affects serum metabolites by modulating the intestinal microflora

This study shows that camel milk modulates gut microbiota and serum metabolites in rats, with beneficial bacteria and metabolites resembling those of healthy individuals.

Transmission bottleneck size estimation from de novo viral genetic variation

This paper estimates transmission bottleneck sizes using de novo viral genetic variation in recipients, finding tight bottlenecks for influenza A and SARS-CoV-2.

Anti-PD-1-iRGD Peptide Conjugate Boosts Antitumor Efficacy via Engagement Augmentation and Penetration Enhancement of T cells

This paper develops a PD-1-iRGD conjugate that enhances antitumor efficacy by improving T cell engagement and penetration, and expands a unique population of CD8+ T cells in the tumor microenvironment.

The super-pangenome of Populus unveil genomic facets for adaptation and diversification in widespread forest trees

The paper constructs a super-pangenome of 19 Populus species to explore genomic factors driving adaptation and diversification in forest trees.

Computational ranking-assisted identification of Plexin-B2 in homotypic and heterotypic clustering of circulating tumor cells in breast cancer metastasis

This study identifies Plexin-B2 as a driver of homotypic and heterotypic CTC clusters in breast cancer metastasis, with high expression linked to poor prognosis and therapeutic potential.

Phosphorylation barcodes direct biased chemokine signaling at CXCR3

The paper shows that CXCR3 chemokines use different phosphorylation barcodes to activate distinct signaling pathways, leading to varied physiological outcomes.

Single cell transcriptomic analysis of renal allograft rejection reveals novel insights into intragraft TCR clonality

The paper uses single-cell RNA sequencing and TCR sequencing to analyze renal allograft rejection, finding CD8+ T cell clonal expansion linked to rejection, independent of immunosuppression type.

Copresent microbiome and short-chain fatty acids profiles of plant biomass utilization in rumen simulation technique system

This study investigates microbiome and short-chain fatty acids (SCFAs) profiles in rumen simulation technique (RUSITEC) systems inoculated with goat and cow rumen contents, identifying copresent microbial genomes associated with substrate degradation.

Public exams decrease anxiety and facilitate deeper conceptual thinking

This study evaluates public exams as an assessment method, finding they reduce anxiety and promote deeper conceptual thinking without worsening outcome disparities.

A streamlined tandem tip-based workflow for sensitive nanoscale phosphoproteomics

This paper introduces a streamlined phosphoproteomics workflow that reduces sample loss and processing time, enabling sensitive detection of phosphopeptides from nanoscale samples.

Genomic insights into present local adaptation and future climate change vulnerability of a keystone forest tree species in East Asian

This study identifies climate-associated genetic variants in Populus koreana and predicts its future climate change vulnerability using genomic and environmental data.

CD81 partners with CD44 in promoting exosome biogenesis, tumor cluster formation, and lung metastasis in triple negative breast cancer

Genomic insights into the phylogeny and biomass-degrading enzymes of rumen ciliates

The paper presents 52 high-quality genomes of rumen ciliates, reclassifying them into 19 species and identifying their biomass-degrading enzymes.

Development of novel in vitro human alveolar epithelial cell models to study distal lung biology and disease

The paper develops novel immortalized human alveolar epithelial cell lines that can form organoids and exhibit lineage memory, offering a new in vitro model for distal lung biology and disease.

DNA damage and oxidizing conditions activate p53 through differential upstream signaling pathways.

The paper investigates how oxidizing conditions activate p53 through two distinct pathways: DNA damage response and stress-activated kinases, showing they can operate independently.

Several FDA-approved drugs effectively inhibit SARS-CoV-2 infection in vitro

This study evaluates 1403 FDA-approved drugs for SARS-CoV-2 inhibition using pseudovirus and authentic virus assays, identifying four compounds with potent effects and a synergistic combination.

Sporadic ERK pulses drive non-genetic resistance in drug-adapted BRAFV600E melanoma cells

The paper shows that sporadic ERK pulses in BRAFV600E melanoma cells drive non-genetic resistance to RAF/MEK inhibitors.

The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells

The paper uses single-cell sequencing to identify non-genetic heterogeneity in serous ovarian cancer by analyzing normal fallopian tube epithelial cells and their subtype signatures.

A transcriptional cycle suited to daytime N2 fixation in the unicellular cyanobacterium Candidatus Atelocyanobacterium thalassa (UCYN-A)

This study identifies how UCYN-A coordinates N2 fixation with metabolism through distinct daily gene cycles, enabling daytime aerobic N2 fixation in a symbiotic relationship with a haptophyte.

Multi-omics analysis of AML cells treated with azacitidine reveals highly variable cell surface proteome remodeling

This study examines how azacitidine affects the DNA methylome, transcriptome, and cell surface proteome of four AML cell lines, revealing pathway-level changes in metabolism and immune response.