S. Pechmann

Pervasive convergent evolution and extreme phenotypes define chaperone requirements of protein homeostasis

This study uses comparative genomics to analyze protein homeostasis across eukaryotes, finding that chaperone network size correlates with genome size and that extreme phenotypes deviate from this trend.

Hsp90 dictates viral sequence space by balancing the evolutionary tradeoffs between protein stability, aggregation and translation rate

The paper shows that reducing Hsp90 activity increases viral sequence diversity by altering the balance between protein stability, aggregation, and translation rate.