A. Acevedo

Thermodynamic Modeling of mRNA with the Addition of Precipitants

This study uses thermodynamic modeling to predict mRNA solubility and identifies hydrogen bonding disruption as a key factor in precipitation.

The BCKDK inhibitor BT2 is a chemical uncoupler that lowers mitochondrial ROS production and de novo lipogenesis

The paper shows BT2 acts as a mitochondrial uncoupler, reducing ROS and lipogenesis, which may explain its therapeutic benefits in metabolic diseases.

Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

This study identifies principles of dengue virus evolvability by analyzing genotype-fitness maps in human and mosquito cells, revealing host-specific adaptation mechanisms and genetic load effects.

Genetic interactions shaping evolutionary trajectories in an RNA virus population

The paper analyzes mutation dynamics in a poliovirus population using high-resolution sequencing to identify interactions like clonal interference and hitchhiking that shape evolutionary trajectories.

An RNA-based system to study hepatitis B virus replication and select drug-resistance mutations

This paper describes an RNA-based system to study HBV replication and predict drug resistance mutations.

Hsp90 dictates viral sequence space by balancing the evolutionary tradeoffs between protein stability, aggregation and translation rate

The paper shows that reducing Hsp90 activity increases viral sequence diversity by altering the balance between protein stability, aggregation, and translation rate.