R. Andino

This study identifies Nsp1's role in enhancing SARS-CoV-2 translation by interacting with EIF1A, leading to reduced viral titers when EIF1A is depleted.

This study identifies a mutation in enterovirus A71 that increases particle stability but reduces cell entry efficiency, revealing structural changes in the capsid.

This paper identifies a viral protein that inhibits stress granule formation by targeting Nup358/RanBP2, revealing a mechanism by which viruses modulate cellular stress responses to promote infection.

The paper investigates how defective interfering genomes affect wild-type poliovirus replication using a mathematical model and experimental data, finding that DI replication and encapsidation are key factors in determining viral competition outcomes.

This study identifies ethacridine, an FDA-approved antiseptic, as a potent inhibitor of SARS-CoV-2 by inactivating viral particles in cellular models.

This study identifies principles of dengue virus evolvability by analyzing genotype-fitness maps in human and mosquito cells, revealing host-specific adaptation mechanisms and genetic load effects.

The paper analyzes mutation dynamics in a poliovirus population using high-resolution sequencing to identify interactions like clonal interference and hitchhiking that shape evolutionary trajectories.

The paper shows that reducing Hsp90 activity increases viral sequence diversity by altering the balance between protein stability, aggregation, and translation rate.