Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspired Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents
S. Perov, O. Lidor, N. Salinas, N. Golan, E. Tayeb-Fligelman, M. Deshmukh, D. Willbold, M. Landau
This paper reveals structural similarities between bacterial curli amyloids and human pathological amyloids, leading to the repurposing of anti-amyloid drugs as anti-biofilm agents.
bioRxiv · Jan 18, 2019 · PreprintBiochemistry