M. Landau

Sea anemone MACPF proteins demonstrate an evolutionary transitional state between venomous and developmental functions

The paper shows MACPF proteins in sea anemones evolved from venomous to developmental functions through gene duplication and reverse-recruitment.

Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics

This study shows that Staphylococcus aureus functional amyloids catalyze the degradation of β-lactam antibiotics, revealing a new mechanism for antibiotic resistance.

Natural Antimicrobial Peptides Self-assemble as α/β Chameleon Amyloids

The paper identifies 14 fibril-forming antimicrobial peptides (ffAMPs) that exhibit cross-β and α/β amyloid properties, suggesting a link between amyloid formation and antimicrobial activity.

Distinct glycerophospholipids potentiate Gsα-activated adenylyl cyclase activity

The paper identifies specific glycerophospholipids that enhance Gsα-activated adenylyl cyclase activity, suggesting an intracellular regulatory role.

Structure and conservation of amyloid spines from the Candida albicans Als5 adhesin including similarity to human LARKS

The paper identifies amyloid-forming sequences in Candida albicans Als5 adhesin and reveals structural similarities to human LARKS, suggesting functional amyloids in fungal pathogenesis.

The Amphibian Antimicrobial Peptide Uperin 3.5 is a Cross-α/Cross-β Chameleon Functional Amyloid

This paper studies the formation of functional amyloid fibrils by the amphibian antimicrobial peptide uperin 3.5, showing its ability to switch between cross-α and cross-β structures under different conditions.

Toxin-like neuropeptides in the sea anemone Nematostella unravel recruitment from the nervous system to venom

The paper identifies a toxin-like neuropeptide in Nematostella vectensis that evolved from a neuropeptide gene into a venom component through duplication and functional specialization.

The Human LL-37(17-29) Antimicrobial Peptide Reveals a Functional Supramolecular Nanostructure

The paper shows LL-37(17-29) forms stable helical fibrils that disrupt bacterial membranes, suggesting a conserved self-assembly mechanism across species.

Staphylococcus aureus PSMα3 Cross-α Fibril Polymorphism and Determinants of Cytotoxicity

This study investigates how PSM3 from Staphylococcus aureus forms cross-α fibrils and how mutations and electrostatic interactions affect its cytotoxicity through membrane co-aggregation.

Structural Insights into Curli CsgA Cross-β Fibril Architecture Inspired Repurposing of Anti-amyloid Compounds as Anti-biofilm Agents

This paper reveals structural similarities between bacterial curli amyloids and human pathological amyloids, leading to the repurposing of anti-amyloid drugs as anti-biofilm agents.

Extreme Amyloid Polymorphism in Staphylococcus aureus Virulent PSMα Peptides

This study investigates the structural diversity of PSM peptides in Staphylococcus aureus, showing that different truncations lead to distinct amyloid fibril architectures with varying functional properties.

Identification of two principal amyloid-driving segments in variable domains of Ig light chains in AL amyloidosis

The paper identifies two independent amyloid-driving segments in Ig light chain variable domains that drive fibril formation in AL amyloidosis and are potential therapeutic targets.

Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.

This study investigates how APOBEC3G selects DNA substrates through structural, biochemical, and functional analyses, revealing key interactions and mechanisms involved in its antiviral activity against HIV-1.