Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B
T. Vögtle, S. Sharma, J. Mori, Z. Nagy, D. Semeniak, M. J. Geer, C. W. Smith, J. Lane, S. Pollack, R. Lassila, A. Jouppila, A. J. Barr, D. J. Ogg, T. D. Howard, H. J. McMiken, , Y. A. Senis
This study identifies heparan sulfate as a critical regulator of G6b-B, showing it inhibits platelet and megakaryocyte function through Shp1/Shp2 signaling.
bioRxiv · Mar 25, 2019Biochemistry