G. J. Wright

Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

The paper identifies potent neutralizing antibodies against the malaria antigen RH5 from natural infection, showing they target similar epitopes as vaccine-induced antibodies.

Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse

The paper uses AlphaFold-Multimer to predict a pentameric complex involved in mammalian egg-sperm fusion, including TMEM81, a previously uncharacterized sperm protein.

Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites

This study identifies the sequential roles of DBP and NBPXa in P. knowlesi merozoite invasion of human RBCs, revealing a phased commitment mechanism that can be targeted with antibodies.

Vivaxin genes encode highly immunogenic non-variant antigens unique to the Trypanosoma vivax cell-surface

The paper identifies a new gene family in Trypanosoma vivax, called vivaxin, which encodes immunogenic surface proteins with potential as vaccine candidates.

LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein

The paper identifies LRRC15 as a novel host factor that interacts with SARS-CoV-2 spike protein, distinct from ACE2 and other known receptors, and shows it modulates viral infection.

An invariant Trypanosoma vivax vaccine antigen inducing protective immunity

This study identifies an invariant Trypanosoma vivax antigen that induces protective immunity through vaccination and monoclonal antibodies.

Structure of the cysteine-rich domain of Plasmodium falciparum P113 identifies the location of the RH5 binding site

The paper determines the structure of the RH5-binding region of P113 and identifies the binding site, providing insights for malaria vaccine development.

No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor

This study investigates whether basigin/CD147 is a direct receptor for SARS-CoV-2 spike protein and finds no evidence of binding.

A screen for Plasmodium falciparum sporozoite surface protein binding to human hepatocyte surface receptors identifies novel host-pathogen interactions

The paper identifies novel host-pathogen interactions between Plasmodium falciparum sporozoite proteins and human hepatocyte surface receptors using a high-throughput screening assay.

A library of cell-surface and secreted proteins from Schistosoma mansoni identifies early serological markers of infection

The paper identifies early serological markers of Schistosoma mansoni infection using a recombinant protein library and mouse infection time series.

Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B

This study identifies heparan sulfate as a critical regulator of G6b-B, showing it inhibits platelet and megakaryocyte function through Shp1/Shp2 signaling.