S. Sharma

Cell state and transcription factor modulation during extended ex vivo CD8+ T-cell expansion.

The paper uses bulk RNA-seq and single-cell RNA-seq data to study T-cell expansion and identifies FOSL1 as a transcription factor that promotes an effector phenotype, enhancing cancer-cell killing.

Microphysiological system modeling pericyte-induced temozolomide resistance in glioblastoma

This paper develops a 3D GBM model with pericytes to study TMZ resistance, finding that pericytes increase TMZ resistance in GBM spheroids by upregulating CCL5.

G-quadruplex formation in long non-coding RNAs dysregulated in colorectal cancer

This study investigates G-quadruplex (G4) formation in three lncRNAs dysregulated in colorectal cancer and shows their stable G4 structures using in silico and in vitro methods.

MICAL2 Is a Super Enhancer Associated Gene that Promotes Pancreatic Cancer Growth and Metastasis

This study identifies MICAL2 as a super enhancer-associated gene that promotes pancreatic cancer growth and metastasis through multiple molecular mechanisms.

Synovial fluid transcriptome dynamics in osteoarthritis progression: Implications in pathogenesis

This study identifies gene expression changes and pathways involved in osteoarthritis progression using synovial fluid transcriptomes from different OA grades.

Assessing mechanisms driving phenol isopropylated phosphate (IPP)- induced larval photomotor response deficits in zebrafish

This study investigates IPP-induced developmental toxicity in zebrafish embryos, finding morphological abnormalities and disrupted larval photomotor responses linked to DNA hypermethylation and gene expression changes in the brain and eye.

Hyperspectral Sensing for High-Throughput Chloride Detection in Grapevines

This paper demonstrates that hyperspectral sensing can identify salinity-tolerant grapevine germplasm with high throughput and non-destructive methods, showing better performance with a more expensive, sensitive device.

Pharmacologic Inhibition of Ferroptosis Attenuates Experimental Abdominal Aortic Aneurysm Formation

This study shows that inhibiting ferroptosis with liproxstatin-1 reduces AAA formation by decreasing inflammation and aortic remodeling in mice.

Expression of a RAS degrader via synthetic nanocarrier-mediated mRNA delivery reduces pancreatic tumors

The paper demonstrates that synthetic nanocarriers deliver RAS-degrading mRNA to pancreatic tumors, reducing RAS levels and tumor growth.

Exploring Probiotic Potential: A Comparative Genomics and In Silico Assessment of Genes within the Genus Geobacillus

This study assesses the probiotic potential of Geobacillus by analyzing its genomic features, revealing safety traits and absence of virulence factors.

Adipose microenvironment promotes hypersialylation of ovarian cancer cells

This study shows that the adipose microenvironment increases sialylation in ovarian cancer cells, promoting tumor growth in immune-dependent settings.

Temporal Single Cell Analysis of Leukemia Microenvironment Identifies Taurine-Taurine Transporter Axis as a Key Regulator of Myeloid Leukemia

This study identifies the taurine-taurine transporter axis as a critical regulator of myeloid leukemia using temporal single-cell RNA-sequencing and functional experiments.

MicroRNA Tae-miR1130p targets wheat ferroportin1 (TaFPN1) in the absence of iron-responsive element/iron-regulatory protein1 module

The paper identifies tae-miR1130b-3p as a regulator of wheat FPN1, showing its negative correlation with TaFPN1 expression and suggesting an alternative regulatory mechanism in plant iron homeostasis.

Cryo- EM structure of ribosome from pathogenic protozoa Entamoeba histolytica, reveals unique features of its architecture

The paper determines cryo-EM structures of E. histolytica ribosomes, revealing unique features like an RNA triple helix and co-evolved rRNA expansion segments.

Discovering Fragile Clades And Causal Sequences In Phylogenomics By Evolutionary Sparse Learning

The paper introduces metrics to identify fragile clades and causal sequences in phylogenomics using evolutionary sparse learning, validated across fungi, plant, and animal datasets.

STING promotes homeostatic maintenance of tissues and confers longevity with aging

This study shows that STING signaling maintains tissue homeostasis and promotes longevity by regulating immune fingerprints and macrophage function during aging.

Flame retardant tetrabromobisphenol A (TBBPA) disrupts histone acetylation during zebrafish maternal-to-zygotic transition

This study shows TBBPA exposure disrupts zebrafish early development by inhibiting histone acetylation during zygotic genome activation.

Resolvin D2/GPR18 signaling enhances monocytic myeloid-derived suppressor cell function to mitigate abdominal aortic aneurysm formation

This study shows RvD2/GPR18 signaling enhances M-MDSC function to reduce AAA formation by suppressing inflammation and vascular remodeling.

Large- and Small-Animal Studies of Safety, Pharmacokinetics (PK), and Biodistribution of Inflammasome-Targeting Nanoligomer in the Brain and Other Target Organs

This paper evaluates the safety, pharmacokinetics, and biodistribution of an inflammasome-targeting Nanoligomer cocktail in small and large animals across multiple administration routes.

Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy

This study shows that Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function in aged and tauopathy mouse models.

Molecular basis of ligand promiscuity, structural mimicry, and atypical dimerization in the chemokine receptors

This study investigates ligand promiscuity and signaling bias in chemokine receptors by analyzing binding modes and determining cryo-EM structures of receptor-ligand complexes.

A genetic and physiological model of renal dysfunction in Lowe syndrome

This study uses a Drosophila nephrocyte model to show that OCRL loss causes endolysosomal defects and kidney dysfunction, which can be rescued by human OCRL but not by mutant variants.

Large pan-cancer cell screen coupled to (phospho-) proteomics underscores high-dose vitamin C as a potent anti-cancer agent

This study evaluates high-dose vitamin C's anti-cancer effects across 51 cancer cell lines, finding high sensitivity and proteomic changes linked to cell cycle and immune pathways.

Haplo-pheno association for OsNRT1.1 paralog in rice reveals superior haplogroup with high nitrate uptake efficiency

The paper identifies superior and inferior haplotypes of OsNRT1.1 paralogs in rice associated with nitrate uptake efficiency through haplo-pheno association analysis.

Drosophila Wg and Evi/Wntless dissociation occurs post apical internalization in the late endosomes

This study identifies that Wnt ligand dissociation from Evi/Wntless occurs post-internalization in acidic endosomes in Drosophila wing epithelial cells.

DeePNAP: A deep learning method to predict protein-nucleic acids binding affinity from sequence

DeePNAP predicts protein-nucleic acid binding affinity and mutation effects from sequence alone, achieving high accuracy using a large heterogeneous dataset.

Tick bite-induced Alpha-Gal Syndrome and Immunologic Responses in an Alpha-Gal Deficient Murine Model

This study investigates how different tick species influence the development of Alpha-Gal Syndrome in a genetically modified mouse model by analyzing immune responses and gene expression.

Whole Genome Sequencing and Assembly of the House Sparrow, Passer domesticus

The paper provides a high-quality whole genome sequence and assembly for the house sparrow, Passer domesticus, which serves as a reference for comparative and population genomic studies.

Phytochemical Characterization of Bio-active Compounds in Hydroethanolic Extract of Elaeocarpus ganitrus leaves using HPLC, LC-MS, and HPTLC Analyses

This study characterizes bioactive compounds in Elaeocarpus ganitrus leaves using HPLC, LC-MS, and HPTLC, identifying 93 compounds with potential therapeutic applications.

Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2

This paper shows telomere length regulates hTERT expression by modulating TRF2 binding and PRC2-mediated repression, revealing a self-regulatory mechanism in cancer.