Cancer BiologybioRxiv
TET2 lesions enhance the aggressiveness of CEBPA-mutant AML by rebalancing GATA2 expression
E. Heyes, A. S. Wilhelmson, A. Wenzel…·B. T. Porse
This study identifies GATA2 as a target of the CEBPA-TET2 mutational axis in AML, showing how TET2 lesions rebalance GATA2 expression and enhance disease aggressiveness.
DOI 10.1038/s41467-023-41927-x