A familial natural short sleep mutation promotes healthy aging and extends lifespan in Drosophila
P. Pandey, P. K. Wall, S. R. Lopez, O. S. Dubuisson, E. R. M. Zunica, W. S. Dantas, J. P. Kirwan, C. L. Axelrod, A. E. Johnson
This study shows that the dec2P384R mutation in Drosophila extends lifespan and improves health by enhancing mitochondrial function and stress response pathways despite reduced sleep.
bioRxiv · Apr 25, 2023 · PreprintCell Biology